147111-30-6

Basic information

• Product Name: 2-(4-bromophenyl)ethanethioamide
• Synonyms: 2-(4-bromophenyl)ethanethioamide
• CAS NO: 147111-30-6
• Molecular Formula: C₈H₈BrNS
• Molecular Weight: 230.13
• Product Categories: Phenyls & Phenyl-Het
• Mol File: 147111-30-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 142-143.5 °C
• Boiling Point: 340.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.564±0.06 g/cm3(Predicted)
• PKA: 12.97±0.29(Predicted)
• CAS DataBase Reference: 2-(4-bromophenyl)ethanethioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)ethanethioamide(147111-30-6)
• EPA Substance Registry System: 2-(4-bromophenyl)ethanethioamide(147111-30-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 147111-30-6(Hazardous Substances Data)

Usage

General Description

2-(4-bromophenyl)ethanethioamide is a chemical compound that belongs to the class of thioamides. It is a yellowish solid with the molecular formula C8H8BrNS. 2-(4-bromophenyl)ethanethioamide is commonly used in various chemical reactions and synthesis processes due to its thioamide functional group, which contains a sulfur atom bonded to an amide group. It is also used in the pharmaceutical industry for the development of potential therapeutic agents, as well as in research laboratories for studying the properties and behaviors of thioamides. Additionally, 2-(4-bromophenyl)ethanethioamide has the potential for various industrial applications, making it a valuable chemical compound with diverse uses.

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 
• 74860-13-2 4-bromobenzeneacetamide 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 

Downstream Products

• 84863-90-1 2-[2-(4-Bromo-benzyl)-thiazol-4-yl]-acetamide 
• 78764-59-7 3-[2-(4-Bromo-benzyl)-thiazol-4-yl]-4-hydroxy-pyrrole-2,5-dione 
• 1318758-61-0 2-(4-bromobenzyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 344255-80-7 [2-(4-Bromo-benzyl)-thiazol-4-yl]-acetic acid ethyl ester 

Relevant articles and documents

Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor

Fibroblast activation protein (FAP) belongs to the family of prolyl-specific serine proteases and displays both exopeptidase and endopeptidase activities. FAP expression is undetectable in most normal adult tissues, but is greatly upregulated in sites of tissue remodeling, which include fibrosis, inflammation and cancer. Due to its restricted expression pattern and dual enzymatic activities, FAP inhibition is investigated as a therapeutic option for several diseases. In the present study, we described the structure–activity relationship of several synthesized compounds against DPPIV and prolyl oligopeptidase (PREP). In particular, BR102910 (compound 24) showed nanomolar potency and high selectivity. Moreover, the in vivo FAP inhibition study of BR102910 (compound 24) using C57BL/6J mice demonstrated exceptional profiles and satisfactory FAP inhibition efficacy. Based on excellent in vitro and in vivo profiles, the potential of BR102910 (compound 24) as a lead candidate for the treatment of type 2 diabetes is considered.

GLUCOSE TRANSPORT INHIBITORS

The present invention relates to quinoline-4-carboxamide derivatives of Formula (I) that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds,