147149-76-6 Usage
Description
Nolatrexed, a potent and selective inhibitor of the enzyme thymidylate synthase, is essential for DNA production. It is a promising pharmaceutical candidate for cancer treatment, working by blocking thymidylate production, leading to DNA damage and cancer cell death. It is typically administered through intravenous infusion and has shown promising results in clinical trials, both as a standalone treatment and in combination with other chemotherapy drugs.
Uses
Used in Oncology:
Nolatrexed is used as an anticancer agent for the treatment of various types of cancer, including non-small cell lung cancer and mesothelioma. It modulates the production of DNA by inhibiting the enzyme thymidylate synthase, exerting inhibitory effects on tumor growth and progression.
Used in Combination Chemotherapy:
Nolatrexed is used in combination with other chemotherapy drugs to enhance the therapeutic outcomes in cancer treatment. It demonstrates synergistic anticancer effects, improving chemo-sensitivity and efficacy in resistant cases.
Used in Clinical Trials:
Nolatrexed is used in clinical trials to explore its potential in treating various types of cancer and to evaluate its safety and efficacy as a standalone treatment or in combination with other chemotherapy agents.
However, like many chemotherapy agents, Nolatrexed can cause a range of side effects, including nausea, vomiting, and bone marrow suppression. Further research and clinical trials are ongoing to optimize its use and minimize side effects in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 147149-76-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,1,4 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 147149-76:
(8*1)+(7*4)+(6*7)+(5*1)+(4*4)+(3*9)+(2*7)+(1*6)=146
146 % 10 = 6
So 147149-76-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)
