14717-30-7

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 89-98-5 2-chloro-benzaldehyde 
• 502-56-7 nonanone-5 
• 1009-14-9 phenyl butyl ketone 
• 7295-44-5 4'-bromovalerophenone 
• 557-20-0 diethylzinc 
• 881404-67-7 (E)-1-(3-bromoprop-1-en-1-yl)-2-chlorobenzene 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 1342886-89-8 2-(2-chlorophenyl)pentanal 
• 1342886-78-5 C₁₁H₁₄BrClO 
• 14469-87-5 5-(2-chlorophenyl)pentan-1-ol 
• 14401-81-1 1,12-Bis-<2-chlor-phenyl>-dodecen-(6) 
• 14491-42-0 1,12-Bis-(2-chlorphenyl)-dodecin-⁽⁶⁾ 
• 14491-45-3 1-Brom-5-(2-chlor-phenyl)-pentan 

Relevant academic research and scientific papers

P-Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

Asymmetric copper-catalyzed allylic alkylation between allyl bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.

SULFAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a sulfamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.

Highly regioselective asymmetric copper-catalyzed allylic alkylation with dialkylzincs using monodentate chiral spiro phosphoramidite and phosphite ligands

The copper complexes of chiral spiro phosphoramidite and phosphite ligands were found to be effective catalysts in the asymmetric allylic alkylations of cinnamyl halides with dialkylzincs. The allylic alkylation products were obtained in high regioselecti

The aldol-Grob reaction: Regioselective synthesis of (E)-alkenes from aldehydes and ketones with ytterbium triflate catalysis

A simple, good yielding and solvent-free aldol-Grob reaction sequence, catalysed by Yb(OTf)3 hydrate, affording (E)-alkenes regioselectively from aldehydes and ketones is described. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Synthesis of (E)-1-Aryl-1-alkenes via a Novel BF3·OEt2-Catalyzed Aldol-Grob Reaction Sequence

The reactions of aromatic aldehydes with ketones in the presence of various acids were examined. The reactions generate (E)-1-aryl-1-alkenes in the presence of boron trifluoride diethyl etherate in nonnucleophilic solvents.

The synthesis of carboxylic acids via an aldol-grob reaction sequence

Ketones react with aromatic aldehydes via a tandem Aldol-Grob reaction sequence. The reaction, initiated by boron trifluoride, produces a carboxylic acid fragment and can serve as an alternative to the Baeyer-Villiger reaction.

Boron trifluoride induced fragmentation of β-Aryl-β-hydroxyketones

β-Aryl-β-hydroxy ketones are readily cleaved by boron trifluoride in non-protic solvents. The reaction appears to proceed via a non-synchronous Grobe fragmentation pathway.

A tandem Aldol-Grob reaction of ketones with aromatic aldehydes

Aromatic aldehydes react with ketones to produce (E)-1-aryl-1-alkenesvia a tandem Aldol-Grob cleavage reaction sequence. The reaction, initiated by boron trifluoride, also produces a carboxylic acid fragment.