14719-83-6Relevant articles and documents
Synthesis of some novel tetrahydronaphthalene benzimidazole derivatives
Ates-Alagoz, Zeynep,Buyukbingol, Erdem
, p. 455 - 460 (2001)
Retinoids, synthetic and natural analogues of all-trans-retinoic acid (RA), exert their biological effects with responsive elements of DNA to promote on cell differentiation and proliferation and behave as potent adipogenic hormones. Herein, we describe the synthesis of a number of novel tetrahydrotetramethylnaphthalene benzimidazole derivatives as retinoids. Analogs were prepared as depicted in Scheme 1 and 2. As is evident from both shemes, a variety of tetrahydrotetramethylnaphthalene benzimidazole derivatives have been synthesized by using an appropiate NaHSO3 addiction product.
Synthesis and applications of novel aminopyrazole derivative
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Paragraph 0132, (2020/04/17)
The invention discloses a novel kinase inhibitor aminopyrazole derivative, a preparation method and medical applications thereof, and more specifically relates to an aminopyrazole derivative containing benzimidazole, and a preparation method thereof, wher
Synthesis and anti-influenza activity of novel thiadiazole, oxadiazole and triazole based scaffolds
Tawfik, Samar S.,Farahat, Abdelbasset A.,El-Sayed, Magda A.-A.,Tantawy, Atif S.,Bagato, Ola,Ali, Mohamed A.
, p. 363 - 374 (2018/04/20)
Background: Influenza is a common respiratory tract infection caused by RNA-virus of the family Orthomyxoviridae; influenza virus, causing variety of symptoms including fever, nasal secretions, cough, muscle pain and pneumonia. It is classified into three distinct types A, B & C. Many 1,3,4-thiadiazoles, 1,3,4-oxadiazoles and 1,2,4-triazoles have showed broad spectrum of biological activities. These heterocycles are considered lead for their high antiviral activity against wide range of viruses. Methods: Research and online content related to chemistry of anti-influenza agents have been reviewed, five schemes were applied to obtain the target compounds, then these compounds underwent in vitro anti-influenza screening. Results: Thirty novel compounds were in vitro screened against the highly pathogenic avian influenza H5N1 virus in MDCK cells. Amantadine was used as control drug. Six compounds showed excellent activity (79-100 % virus inhibition) namely 6c, 14b, 14c, 19b, 30b, 30e with 14c being the most active compound. Five compounds exhibited moderate inhibition (44-70%) namely 5c, 6b, 23a, 23b, 30c. Conclusion: From the previous results, we found that presence of the triazole ring decreased the antiviral activity. While compound 19b that contains benzimidazole nucleus showed excellent inhibition. Presence of the thiadiazole ring greatly affected the activity in different ways according to the substitution on the ring. Moving to the oxadiazole series 14a-c, 16, 28b,c and 30a-f, the change in substitutions greatly affected the antiviral activity. Presence of 4-tolyl or 4-chlorophenyl at position 5 of the oxadiazole greatly enhanced the activity in 14b,c.
nepal reaches Neeb process and intermediates for the synthesis of (by machine translation)
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Paragraph 0046; 0064; 0065, (2016/11/02)
The invention discloses a method for synthesizing nepal reaches Neeb and intermediates thereof, the synthesis method comprises: under acidic conditions, the compound of formula (II) reaction of a compound of the formula (I) compound of formula (III); compound (III) of the detached with acid uncle Ding Zhiji carbonate, adding alkali reaction of the compound of formula (V); the compound of formula (V) reaction with chloroacetic acid derivatives of formula (VI) the activation of the compound, then the reaction-methyl piperazine N, obtain nepal reaches Neeb. The present invention provides a mild reaction conditions of a new method for synthesizing nepal reaches Neeb, the invention also provides synthetic intermediates nepal reaches Neeb. (by machine translation)
