147194-24-9Relevant academic research and scientific papers
Conversion of epoxides into 2-hydroxyethyl thiocyanates with NH 4SCN in the presense of 2,6-BIS[2-(O-amino phenoxy)methyl]-4-bromo-1- methoxybenzene (BABMB) as catalyst
Niknam, Khodabakhsh
, p. 499 - 506 (2004)
A convenient and efficient procedure for the ring-opening of 1,2-epoxyethanes with ammonium thiocyanate in the presence of 2,6-bis[2-(o-aminophenoxy)methyl]-4-bromo-1-methoxybenzene (BABMB) is described. In this study, a reagent and conditions have been discovered with which the individual 2-hydroxyethyl thiocyanates can be synthesized in high yield and with more than 90% regioselectivity. Thus, several 2-hydroxyethyl thiocyanates, useful intermediates toward biological-active molecules, are easily obtained in very good yields.
