1471990-77-8Relevant academic research and scientific papers
Pd(ii)-catalyzed alkylation of unactivated C(sp3)-H bonds: Efficient synthesis of optically active unnatural α-amino acids
Chen, Kai,Hu, Fang,Zhang, Shuo-Qing,Shi, Bing-Feng
, p. 3906 - 3911 (2013/09/23)
A palladium-catalyzed alkylation of primary and secondary C(sp 3)-H bonds with alkyl iodides and/or bromides for the synthesis of optically active unnatural α-amino acids (α-AAs) is described. This process is scalable and tolerates a variety of functional groups with complete retention of chirality, providing an efficient new strategy for the synthesis of various unnatural α-amino acid derivatives.
