147221-33-8Relevant articles and documents
Development of oxetane modified building blocks for peptide synthesis
Beadle, Jonathan D.,Clarkson, Guy J.,Raubo, Piotr,Roesner, Stefan,Shipman, Michael,Tam, Leo K. B.,Wilkening, Ina
, p. 5400 - 5405 (2020)
The synthesis and use of oxetane modified dipeptide building blocks in solution and solid-phase peptide synthesis (SPPS) is reported. The preparation of building blocks containing non-glycine residues at the N-terminus in a stereochemically controlled man
Synthesis of Silacyclic Dipeptides: Peptide Elongation at Both N-And C-Termini of Dipeptide
Hattori, Tomohiro,Yamamoto, Hisashi
supporting information, (2022/02/01)
A new type of peptide bond formation utilizing silacyclic amino acids or peptides is described. This work has the following advantages: (1) imidazolylsilane is a highly fascinating coupling reagent for dipeptide synthesis from N-,C-Terminal unprotected am
MACROCYCLIZATION OF PEPTIDOMIMETICS
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Page/Page column 36; 41-42; 48-49, (2019/10/19)
The invention provides an improved method of macrocyclization of peptidomimetics, as measured by isolated yields and product distribution, which comprises substitution of one or more of the backbone amide C=O bonds with a turn-inducing motif. The method is general with enhancements seen across a range of ring sizes (e.g. tri-, tetra-, penta- and hexapeptides). Specifically, the invention provides a peptidomimetic macrocycle comprising a carbonyl bioisosteric turn-inducing element having the structure: (I) wherein X is a heteroatom; and wherein R1 to R6 are each independently selected from alkyl, aryl, heteroaryl and H.
