147223-89-0

Upstream product

• 24484-55-7 1-bromo-3-(4-fluorophenyl)propane 
• 85102-99-4 1-benzyl-1H-imidazole-5-carboxaldehyde 
• 147223-88-9 1-benzyl-5-[4-(4-fluorophenyl)-1-oxobutyl]-1H-imidazole 
• 147223-87-8 1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole 
• 42498-38-4 N-(tert-butyl)-4-bromobenzamide 

Downstream Products

• 147223-90-3 4-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole 

Relevant academic research and scientific papers

Synthesis of new potent and selective aromatase inhibitors based on long-chained diarylalkylimidazole and diarylalkyltriazole molecule skeletons

A series of long-chained diarylalkylimidazoles and diarylalkyltriazoles were synthesized and evaluated for the inhibitory potency for aromatase (estrogen synthetase) activity in human placental microsomes. The relative specificity of inhibition was evaluated by measuring the inhibition of cholesterol side-chain cleavage enzyme (desmolase) in human placental mitochondria and the inhibition of 7-ethoxycoumarin O-deethylase (a typical drug-metabolizing enzyme activity) in rat liver microsomes. The structural requirements including substituent effects for the strongest potency and for the highest specificity were delineated. α,ω-Diarylalkyltriazoles and imidazoles were the most interesting molecules, in which the geometric and optical isomerism displayed remarkable selectivity for aromatase inhibition. Copyright (C) 2000 Elsevier Science B.V.

Selective aromatase inhibiting 4(5)-imidazoles

PCT No. PCT/FI92/00184 Sec. 371 Date May 9, 1994 Sec. 102(e) Date May 9, 1994 PCT Filed Jun. 12, 1992 PCT Pub. No. WO92/22537 PCT Pub. Date Dec. 23, 1992 (Ia) (Ib) (II) New 4(5)-imidazole derivatives of formula (Ia) and (Ib) wherei