147245-92-9

Basic information

• Product Name: Glatiramer acetate
• Synonyms: GLATIRAMER ACETATE;l-glutamic acid polymer with l-alanine, l-lysine and l-tyrosine, acetate (salt);511: PN: WO2010103292 PAGE: 64 claiMed sequence;L-Alanine polyMer with L-GlutaMic Acid L-Lysine L-Tyrosine Acetate;L-GlutaMic Acid peptide with L-Alanine L-Lysine L-Tyrosine Acetate Salt;L-Tyrosine polyMer with L-Alanine L-GlutaMic Acid L-Lysine Acetate;ProtiraMer;GaltiraMer acetate
• CAS NO: 147245-92-9
• Molecular Formula: C25H45N5O13
• Molecular Weight: 623.6505
• EINECS: 1592732-453-0
• Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;API
• Mol File: 147245-92-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 385.2oC at 760mmHg
• Flash Point: 186.7oC
• Appearance: /
• Vapor Pressure: 1.27E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: Glatiramer acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Glatiramer acetate(147245-92-9)
• EPA Substance Registry System: Glatiramer acetate(147245-92-9)

Safety Data

• Hazardous Substances Data: 147245-92-9(Hazardous Substances Data)

Usage

Originator

Copaxone,Teva Pharmaceuticals,Israel

Uses

Different sources of media describe the Uses of 147245-92-9 differently. You can refer to the following data:
1. Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.
2. Glatiramer Acetate-Dx is labelled Glatiramer Acetate (G406800) which is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis.

Manufacturing Process

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000. Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Brand name

Copaxone (Teva).

Clinical Use

Immunomodulating drug: Treatment for patients at a high risk of developing multiple sclerosis and for reduction in relapses in ambulatory patients

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

A substantial fraction of a subcutaneous dose of glatiramer is believed to be hydrolysed locally. Some of the injected dose is also presumed to enter the lymphatic system, either intact or partially hydrolysed.

InChI:InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1