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147245-92-9 Usage


Glatiramer acetate is a synthetic compound, and its production involves the polymerization of the mentioned amino acids in a specific molar ratio.
Production Methods:
The synthesis of glatiramer acetate involves the random copolymerization of L-alanine, L-lysine, l-glutamic acid, and L-tyrosine using standard polymerization techniques. The resulting copolymer is then purified and characterized to ensure its quality and consistency.


Used in Pharmaceutical Industry:
Glatiramer acetate is used as an immunomodulator for the treatment of multiple sclerosis (MS). It functions by modulating the immune system's response to myelin basic protein, which is a component of the myelin sheath that insulates nerve fibers. By altering the immune response, glatiramer acetate helps reduce the frequency and severity of MS relapses.
Used in Multiple Sclerosis Treatment:
Glatiramer acetate is used as a therapeutic agent for patients with relapsing-remitting multiple sclerosis (RRMS). It is administered through subcutaneous injections and has been shown to decrease the number of relapses and slow the progression of physical disability in RRMS patients.
Brand Name:
Copaxone (Teva) is the brand name under which glatiramer acetate is marketed. It is available in pre-filled syringes and auto-injectors for the convenience of patients and healthcare providers.


Copaxone,Teva Pharmaceuticals,Israel

Manufacturing Process

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000. Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Clinical Use

Immunomodulating drug: Treatment for patients at a high risk of developing multiple sclerosis and for reduction in relapses in ambulatory patients

Drug interactions

Potentially hazardous interactions with other drugs None known


A substantial fraction of a subcutaneous dose of glatiramer is believed to be hydrolysed locally. Some of the injected dose is also presumed to enter the lymphatic system, either intact or partially hydrolysed.

Check Digit Verification of cas no

The CAS Registry Mumber 147245-92-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,2,4 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147245-92:
139 % 10 = 9
So 147245-92-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name acetic acid,(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid,(2S)-2-aminopentanedioic acid,(2S)-2-aminopropanoic acid,(2S)-2,6-diaminohexanoic acid

1.2 Other means of identification

Product number -
Other names Glatiramer acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147245-92-9 SDS

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