147252-96-8

Upstream product

• 52340-78-0 (R,R)-hydroxybenzoin 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 147252-97-9 (5R,6R)-5,6-diphenyl-4-oxa-6-(tert-butyldimethylsilyloxy)-1-hexene 
• 147252-98-0 (4R,5R)-4,5-diphenyl-3-oxa-5-(tert-butyldimethylsilyloxy)-1-pentanol 
• 147253-01-8 (1R,2R,7R,8R)-1,2,7,8-tetraphenyl-3,6-dioxa-1,8-octanediol 
• 147252-99-1 (1R,2R)-1,2-diphenyl-1-(tert-butyldimethylsilyloxy)-5-(p-toluenesulfonyloxy)-3-oxapentane 
• 147253-00-7 (1R,2R,7R,8R)-1,2,7,8-tetraphenyl-3,6-dioxa-1,8-bis(tert-butyldimethylsilyloxy)octane 

Relevant academic research and scientific papers

The synthesis of a chiral hexaphenyl-18-crown-6 derivative

The stereospecific synthesis of (2R,3R,8R,9R,14R,15R)-2,3,8,9,14,15-hexaphenyl-1,4,7,10,13,16- hexaoxacyclooctadedecane [(R,R,R,R,R,R)-12] from (R,R)-hydrobenzoin [(R,R)-1] is reported. The ability of (R,R,R,R,R,R)-12 to act as a chiral solid-liquid phase

Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary

The atropo-selective coupling of in situ generated arynes and aryllithiums bearing various chiral auxiliaries ortho to lithium (tert-butylsulfoxide, para-tolylsulfoxide, tartrate-derived chiral diethers and oxazolines) is described. Chiral oxazolines showed the best results in terms of yields of coupling products. Different reaction parameters like the nature of the aryne precursor, the oxazoline, the alkyllithium base or the solvent revealed to be crucial for obtaining good yields and for diastereoselection.