1472624-85-3

Basic information

• Product Name: 7ACC-2
• Synonyms: 7ACC 2;7ACC2;7ACC-2;7-[Benzyl(methyl)amino]-2-oxo-2H-chromene-3-carboxylic acid
• CAS NO: 1472624-85-3
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.316
• EINECS: 604-604-1
• Product Categories: Inhibitors
• Mol File: 1472624-85-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 548.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.368±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: insoluble in EtOH; insoluble in H2O; ≥47.5 mg/mL in DMSO
• PKA: -98.37±0.20(Predicted)
• CAS DataBase Reference: 7ACC-2(CAS DataBase Reference)
• NIST Chemistry Reference: 7ACC-2(1472624-85-3)
• EPA Substance Registry System: 7ACC-2(1472624-85-3)

Safety Data

• Hazardous Substances Data: 1472624-85-3(Hazardous Substances Data)

Usage

Biological Activity

7acc2, a carboxycoumarin derivative, is a potent inhibitor of monocarboxylate transporter 1 (mct1), with an ic50 value of ~ 10 nm for lactate uptake in the human cervix carcinoma cell line siha. the family of mct is composed of 14 members, among which only four isoforms (i.e. mct1-4) have been documented to act as proton-linked transporters carrying short chain monocarboxylates such as lactate and pyruvate across cell membranes. in cancer cells, mct1 and mct4 are the most widely expressed, and mct1 shows a better affinity for l-lactate than mct4, enabling lactate entry into oxidative tumor cells. thus, mct1 blockade could serve as a potential therapeutic strategy to limit cancer progression. in addition, 7acc2 is also a potent inhibitor of mitochondrial pyruvate transport, which interferes with pyruvate import into mitochondria and ultimately prevents extracellular lactate uptake as efficiently as a mct1 inhibitor.1. draoui n, schicke o, fernandes a, et al. synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. bioorganic & medicinal chemistry, 2013, 21(22): 7107-7117.2. corbet c, bastien e, draoui n, et al. interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. nature communications, 2018, 9(1): 1208.