1472651-75-4Relevant academic research and scientific papers
Synthesis and characterization of isothiobiurets of N-glucosylated compounds and their antimicrobial activities
Sarap, Ashish G.,Deshmukh, Shirish P.
, p. 1015 - 1018 (2013/09/23)
A series of several 1-aryl-5-tetra-O-acetyl-β-glucopyranosyl-2-S- benzyl-2-isothiobiurets have been prepared by the interaction of aryl S-benzylisothiocarbamides and tetra-O-acetyl-β-glucopyranosyl isocyanate. The required aryl S-benzylisothiocarbamides was prepared by S-benzylation of different thioureas and tetra-O-acetyl-β-D-glucopyranosyl isocyanate was prepared by interaction of tetra-O-acetyl-α-D-glucopyranosyl bromide and lead cyanate. The structures of the newly synthesized compounds have been established on the basis of usual chemical transformations and IR, 1H NMR and Mass spectral studies. All the synthesized compounds have been evaluated for their in vitro antibacterial and antifungal activity against different bacteria and fungi by agar diffusion method.
