147269-06-5

Basic information

• Product Name: 6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile
• Synonyms: 6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile;2-hydroxy-6-(4-methoxyphenyl)pyridine-3-carbonitrile
• CAS NO: 147269-06-5
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.24
• Mol File: 147269-06-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(147269-06-5)
• EPA Substance Registry System: 6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile(147269-06-5)

Safety Data

• Hazardous Substances Data: 147269-06-5(Hazardous Substances Data)

Upstream product

• 18096-70-3 3-(dimethylamino)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 107-91-5 cyanoacetic acid amide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 109-94-4 formic acid ethyl ester 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 

Downstream Products

• 1242622-20-3 3-cyano-6-(4-methoxyphenyl)pyrimidin-2-yl diisopropyl phosphate 
• 393139-94-1 3-cyano-6-(4-methoxyphenyl)pyridin-2-yl diethyl phosphate 
• 147269-09-8 2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 306977-92-4 C₁₄H₁₂N₂O₂ 
• 147269-10-1 2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147269-08-7 3-benzyloxycarbonylamino-6-(4-methoxyphenyl)pyrid-2-one 
• 583039-77-4 4-(3-amino-5-bromo-1H-pyrazolo[3,4-b]pyridin-6-yl)-phenol 
• 583039-76-3 5-bromo-6-(4-methoxyphenyl)-1H-pyrazolo[3,4-b]pyridine-3-amine 
• 583039-75-2 5-bromo-2-chloro-6-(4-methoxy-phenyl)-nicotinonitrile 
• 951907-79-2 6-(4-methoxy-phenyl)-1H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 583039-74-1 5-bromo-6-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 306977-91-3 2-chloro-6-(4-methoxyphenyl)nicotinonitrile 
• 147269-07-6 6-(4-methoxyphenyl)pyrid-2-one-3-carboxylic acid 

Relevant articles and documents

ANTIVIRAL COMPOUNDS

A compound can include the structure of Formula 1, derivative thereof, prodrug thereof, salt thereof, stereoisomer thereof, tautomer thereof, polymorph thereof, or solvate thereof, or having any chirality at any chiral center: R1 includes a hyd

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

Is the herbicidal activity of 3-cyanopyridin-2-yl phosphates related to phosphatase?

The herbicidal activity of 3-cyanopyridin-2-yl phosphates, which were designed according to the idea of a mechanism-based inactivator, is probably related to a phosphatase. Taylor & Francis Group, LLC.

Synthesis of the pyridone analogues of territrem B

Two series of territrem B analogues were synthesised in nine linear steps from commercially available starting materials.

6-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)

A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones

A series of potent nonpeptidic inhibitors of the enzyme human leukocyte elastase (HLE) is reported. These inhibitors contain a 3-amino-2-pyridone ring as a central template in which the pyridone carbonyl and 3-position NH group are thought to form important hydrogen bonding interactions with the Val-216 residue of HLE. Substitution of the 6-position of the pyridone ring by various alkyl and aryl groups was found to afford increases in the in vitro potency of these inhibitors. A 6-position phenyl group, compound 10f, was found to result in a large increase in binding affinity, which was not obtained when the phenyl group was placed in either the 4- or 5-position of the molecule. Compound 10f was found to have good selectivity for HLE over other proteolytic enzymes, with the exception of bovine pancreatic chymotrypsin (BPC). Substitution of the 6-phenyl group in these molecules was found to decrease binding affinity for BPC without adversely affecting affinity for HLE.