147283-69-0

Upstream product

• 106746-09-2 3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride 
• 184710-75-6 2-(3-benzyloxycarbonylamino-5-benzyl-2-oxo-1,2-dihydro-1-pyridyl)acetic acid 
• 147283-72-5 (5-Benzyl-3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester 
• 147283-71-4 5-Benzyl-3-benzyloxycarbonylamino-pyrid-2-one 
• 147269-68-9 3-<<(benzyloxy)carbonyl>amino>-5-iodopyrid-2-one 
• 147269-67-8 3-(benzyloxycarbonylamino)pyrid-2-one 
• 33630-99-8 3-amino-2-pyridone 
• 6332-56-5 3-nitropyridone 

Downstream Products

• 147267-87-6 2-(5-Benzyl-3-benzyloxycarbonylamino-2-oxo-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 147313-63-1 2-(3-Amino-5-benzyl-2-oxo-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide 
• 147268-12-0 N-{5-Benzyl-2-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-oxalamic acid methyl ester 

Relevant academic research and scientific papers

Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors

Human leukocyte elastase (HLE) is a serine protease produced by neutrophils that has been implicated in diseases such as amphysema and cystic fibrosis. An HLE inhibitor may have therapeutic value in these diseases. An active site model of HLE bound to a t