14729-29-4 Usage
Description
Roridin A, a toxic macrocyclic trichothecene compound, is produced by the fungus Stachybotrys chartarum, commonly referred to as black mold. It is a member of the mycotoxins, which are toxic secondary metabolites generated by mold and fungi. RORIDIN A is a potent inhibitor of protein synthesis in eukaryotic cells and is linked to a wide array of toxic effects such as cytotoxicity, immunosuppression, and genotoxicity. Due to its association with severe health issues like respiratory problems, skin irritation, and systemic toxicity, it is imperative to prevent exposure to Stachybotrys chartarum and any potential sources of roridin A contamination.
Given the provided materials, there are no specific applications listed for Roridin A due to its highly toxic nature. However, in a general context, the study and understanding of such compounds are crucial for the development of detection methods, prevention strategies, and potential antidotes or treatments for mycotoxin-related health issues. If there were applications, they would be described as follows:
Used in Research and Development Industry:
Roridin A is used as a subject of study for understanding its toxicological properties and developing methods of detection and prevention of its harmful effects.
Used in Public Health and Safety Measures:
Roridin A is considered in the development of guidelines and regulations to prevent exposure and contamination from Stachybotrys chartarum, thereby protecting public health.
Check Digit Verification of cas no
The CAS Registry Mumber 14729-29-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,2 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14729-29:
(7*1)+(6*4)+(5*7)+(4*2)+(3*9)+(2*2)+(1*9)=114
114 % 10 = 4
So 14729-29-4 is a valid CAS Registry Number.
InChI:InChI=1/C29H40O9/c1-17-9-11-28-15-35-26(33)25(32)18(2)10-12-34-20(19(3)30)7-5-6-8-24(31)38-21-14-23(37-22(28)13-17)29(16-36-29)27(21,28)4/h5-8,13,18-23,25,30,32H,9-12,14-16H2,1-4H3/b7-5-,8-6-/t18-,19-,20-,21-,22-,23-,25+,27-,28-,29-/m1/s1
14729-29-4Relevant articles and documents
Isolation and Characterization of the Trichoverroids and New Roridins and Verrucarins
Jarvis, Bruce B.,Stahly, G. Patrick,Pavanasasivam, Gowsala,Midiwo, Jacob O.,DeSilva, Tuley,Holmlund, Chester E.
, p. 1117 - 1124 (2007/10/02)
Myrothecium verrucaria grown on a large scale (760 L) has yielded a variety of new trichothecenes including the nonmacrocyclic trichoverroids 13-19, which contain a pendant C4 cis,trans-dienic ester side chain normally common only to the macrocyclic roridins and verrucarins.Several novel macrocyclic trichothecenes (roridins J and K acetate) and verrucarins L and L acetate also were isolated and characterized.
