147298-50-8

Usage

Molecular structure

1H-Pyrrole-3-carboxylic acid, 2-(4-bromophenyl)-2,5-dihydro-4-hydroxy-5-oxo-1-phenyl-, ethyl ester is an ethyl ester derivative of 1H-pyrrole-3-carboxylic acid, containing a 4-bromophenyl group and a phenyl group.

Potential pharmaceutical applications

The compound has potential pharmaceutical applications due to its unique structure and possible biological activities.

Biological activities

The presence of hydroxy and oxo groups in its structure suggests that it may have potential biological activities, such as antioxidant or enzyme inhibitory properties.

Lack of extensive study

1H-Pyrrole-3-carboxylic acid, 2-(4-bromophenyl)-2,5-dihydro-4-hydroxy-5-oxo-1-phenyl-, ethyl ester has not been extensively studied, indicating that further research is needed to fully understand its properties and potential applications.

Valuable scaffold

The compound's structural features indicate that it could be a valuable scaffold for the development of new drug candidates.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 62-53-3 aniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 131189-30-5 4-Benzhydryloxy-2-(4-bromo-phenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 
• 131189-35-0 3-Benzhydryl-2-(4-bromo-phenyl)-4,5-dioxo-1-phenyl-pyrrolidine-3-carboxylic acid ethyl ester 
• 131189-39-4 5-p-Bromophenyl-3-methoxy-1-phenyl-4-ethoxycarbonyl-2,5-dihydropyrrol-2-one 

Relevant academic research and scientific papers

Malic acid as an effective and valuable bioorganocatalyst for one-pot, three-component synthesis of pyrrolidinone derivatives

Malic acid was used as an effective and valuable bioorganocatalyst for the one-pot, three-component synthesis of important and noteworthy pyrrolidinone derivatives in green solvent at 50oC. Ecofriendly, simplicity in operation, cleaner reaction profile, s

Visible light-promoted synthesis of pyrrolidinone derivatives via Rose Bengal as a photoredox catalyst and their photophysical studies

Herein, we report an intramolecular radical cyclization reaction towards the synthesis of pyrrolidinone derivatives via metal-free photoredox catalysis under irradiation from blue LEDs. Some of the remarkable features of this protocol include synthetic ef

Synthesis of Ethyl 3-Methyl-4,5-dioxo-1,2-diphenylpyrrolidine-3-carboxylate Analogues Using Green and Expeditious Grinding Method

Abstract: A specific efficient method of synthesis of biologically active analogues of the title compound from acetylene dicarboxylate, aniline and various aromatic aldehydes catalyzed by citric acid by one-pot mortar-pestle grinding is described. The sho

Magnetic cobalt ferrite nanoparticles functionalized with citric acid as a green nanocatalyst for one-pot three-component sonochemical synthesis of substituted 3-pyrrolin-2-ones

Abstract: A clean, convenient and facile approach for one-pot ultrasonic assisted synthesis of substituted 3-pyrrolin-2-ones from diethyl acetylenedicarboxylate, aniline and aldehyde derivatives is described. The reactions were carried out in the presence

An Efficient Synthesis of Pyrrolidinone Derivatives in the Presence of 1,1′-Butylenebis(3-sulfo-3 H -imidazol-1-ium) Chloride

The catalytic efficiency of 1,1′-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid-functionalized ionic liquid was demonstrated for the synthesis of pyrrolidinone derivatives under mild conditions. The electronic effect of substituents on aniline derivatives was investigated. Further, a study on the structure-activity relationship of ionic liquids containing sulfonic groups for the synthesis of ethyl-2-(4-chlorophenyl)-4-hydroxy-5-oxo-1-(p-tolyl)-2,5-dihydro-1H-pyrrole-3-carboxylate was performed under optimal conditions. The results showed that the catalytic properties of ionic liquids containing two sulfonic or imidazole moieties with carbon spacers was superior to ionic liquids having one sulfonic or imidazole moiety with no carbon spacer.

Synthesis of pyrrolidinone derivatives from aniline, an aldehyde and diethyl acetylenedicarboxylate in an ethanolic citric acid solution under ultrasound irradiation

The ultrasound-promoted one-pot multicomponent synthesis of substituted 3-pyrrolin-2-ones using citric acid as a green additive in a green solvent is reported. Citric acid catalyzed the reaction efficiently without the need for any other harmful organic r

In-water facile synthesis of poly-substituted 6-arylamino pyridines and 2-pyrrolidone derivatives using tetragonal nano-ZrO2 as reusable catalyst

Here, we report a facile synthetic protocol to access a series of ethyl 5-cyano-2-methyl-4-aryl-6-(arylamino)nicotinates and ethyl 4-hydroxy-2-(4-nitroaryl)-5-oxo-1-aryl-2,5-dihydro-1H-pyrrole-3-carboxylates using tetragonal nano-ZrO2 as reusab