1473-60-5

Usage

InChI:InChI=1/C16H11NO3/c18-14-7-3-1-6-12(14)10-17-13-9-11-5-2-4-8-15(11)20-16(13)19/h1-10,17H/b12-10+

Upstream product

• 90-02-8 salicylaldehyde 
• 616-34-2 methoxycarbonylmethylamine 
• 779-30-6 3-acetamidocoumarin 
• 623-33-6 glycine ethyl ester hydrochloride 
• 1635-31-0 aminocoumarine 

Downstream Products

• 112517-48-3 C₂₂H₁₃Cl₂N₃O₃ 
• 134268-98-7 Boc-Phe-NH-c 
• 112517-46-1 C₂₂H₁₅N₃O₄ 
• 112517-44-9 C₂₂H₁₅N₃O₃ 
• 112517-45-0 C₂₂H₁₄ClN₃O₃ 
• 97472-95-2 3-salicylaminocoumarin 
• 709-16-0 2-hydroxy-phenylalanine 
• 1635-31-0 aminocoumarine 
• 939-19-5 3-Hydroxy-cumarin 
• 112517-47-2 C₂₂H₁₃Cl₂N₃O₃ 

Relevant academic research and scientific papers

A novel coumarinyl scaffold as metal ion sensor towards spectrophotometric detection of Cu2+, Ni2+ and Zn2+ ion

A new series of coumarin based metal ion sensors have been prepared devising a green protocol involving ethyl-(L)-lactate as a polar solvent. These compounds either selectively bind with specific transitional metal ions or form complexes with specific photophysical character when subjected to absorption spectroscopy. The derived Schiff's bases quantitatively bind with metal ions to form 1:1 complexes making them a useful tool for qualitative estimation of metal ions in biological as well as organic systems.

Hydroxycoumarin derivatives: Novel and potent α-glucosidase inhibitors

A novel class of hydroxycoumarin derivatives were found to be potent α-glucosidase inhibitors. Their syntheses were reported and the structure-activity relationship was established. Kinetic enzymatic assays indicated that compound 10 was a slow-binding and noncompetitive inhibitor with a Ki value of 589 nM, while compound 11 was a competitive inhibitor with a Ki value of 4.810 μM. Among all hydroxycoumarin derivatives studied, compounds 10 and 11 exhibited the highest activities, were specific inhibitors of α-glucosidase, and could be exploited as the lead compounds for the development of potent α-glucosidase inhibitors. Compounds 10 and 11 were also selected for further discussion for the mechanism of enzymatic inhibition.

Synthesis of 3-[α-(3-Chloro-2-oxo-4-substituted-phenyl/furfuryl-1-azetidinyl)]-2H-1- benzopyran-2-ones and 3-[α-(2-Substituted-phenyl/furfurylthiazolidiznyl)]-2H-1-benzopyran-2-ones as C.N.S. -active Agents

Reaction of 3-substituted-phenylidine/furfurylidineamino-2H-1-benzopyran-2-ones (3a-d) with chloroacetyl chloride and thioglycolic acid affords the corresponding four-membered azetidinones (4a-d) and five-membered thiazolidinones (5a-d) respectively. All the compounds were tested for their acute toxicity, effects on gross behaviour, spontaneous motor activity (SMA), anorexigenic activity, neuroleptic activity and anticonvulsant activity. Compounds 4a and 5d exhibited C.N.S. depressant activity.

Synthesis and anti-inflammatory activity of 3-(benzylideneamino)coumarins in rodents

A series of substituted 3-(benzylideneamino)coumarins was synthesized and evaluated for anti-inflammatory activity against carrageenan-induced edema in rats. Halogenated derivatives 4g and 4c, at oral doses of 100 mg/kg, showed 75 and 60% antiedematous ac

Synthesis of 3-(&α-Arylazo-benzylideneamino/furfurylideneamino)coumarins and Their Anti-inflammatory Activity

3-(α-Arylazo-benzylideneamino/furfurylideneamino)coumarins (IVa-k) have been prepared by the coupling reaction of 3-arylidene-aminocoumarins (IIIa-c) with arenediazonium chlorides.The coumarins III in turn have been obtained by condensation of appropriate aldehydes with 3-aminocoumarin (II).An improved synthesis of 3-aminocoumarin (II) is also described.