147300-17-2

Basic information

• Product Name: 4-{[(3-methoxyphenyl)imino]methyl}benzonitrile
• Synonyms: 4-{[(3-methoxyphenyl)imino]methyl}benzonitrile;4-{(E)-[(3-methoxyphenyl)imino]methyl}benzonitrile
• CAS NO: 147300-17-2
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.27
• Mol File: 147300-17-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-{[(3-methoxyphenyl)imino]methyl}benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(3-methoxyphenyl)imino]methyl}benzonitrile(147300-17-2)
• EPA Substance Registry System: 4-{[(3-methoxyphenyl)imino]methyl}benzonitrile(147300-17-2)

Safety Data

• Hazardous Substances Data: 147300-17-2(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 105-07-7 4-cyanobenzaldehyde 

Downstream Products

• 1428969-08-7 4-(2-(7-chloro-1H-indol-3-yl)-1-((3-methoxyphenyl)amino)-2-oxoethyl)benzonitrile 
• 1428968-20-0 4-(2-(1H-indol-3-yl)-1-((3-methoxyphenyl)amino)-2-oxoethyl)benzonitrile 

Relevant articles and documents

Substituent effects on the stretching vibration of C═N in multi-substituted benzylideneanilines

Forty-nine samples of 3,4′/4,3′/3,3′-disubstituted benzylideneanilines (XBAYs) and 52 samples of multi-substituted XBAYs were synthesized, and their infrared absorption spectra were recorded in this paper. On the basis of the stretching vibration frequencies νC═N of C═N bridging bond of 158 samples of substituted XBAYs (including 57 samples of 4,4′-disubstituted XBAYs from reference and 101 samples of substituted XBAYs synthesized in this paper), an extensional research of substituent effects on the νC═N values from 4,4′-disubstituted XBAYs to multi-substituted XBAYs was made. A modified equation for quantifying the νC═N values of multi-substituted XBAYs was obtained (shown as Equation (3)). Equation (3) indicates that the excited-state substituent constant of Y and the substituent specific cross-interaction effect between X and X cannot be ignored for the quantitative regression analysis of the νC═N values of multi-substituted XBAYs. Compared with Equation (1), Equation (3) has a wider application and more accuracy in quantifying the νC═N values of substituted XBAYs.

Comparison of the substituent effects on the 13C NMR with the 1H NMR chemical shifts of CH=N in substituted benzylideneanilines

Fifty-two samples of substituted benzylideneanilines XPhCH=NPhYs (XBAYs) were synthesized, and their NMR spectra were determined in this paper. Together with the NMR data of other 77 samples of XBAYs quoted from literatures, the 1H NMR chemical

VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.