147322-24-5Relevant academic research and scientific papers
TRIPHENYLETHYLENE DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME
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, (2008/06/13)
A triphenylalkene derivative represented by general formula (1), a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical composition thereof having a tumor inhibitory action and an osteoporosis curing activity. In general formula (1) R1 represents a group selected among those represented by formulae (2), (3) and (4); R6 and R7 represent each hydrogen, alkyl or cycloalkyl, or R6 and R7 together form a heterocyclic group with the adjacent nitrogen atom, provided that R6 and R7 should not be hydrogen atoms at the same time; R8 represents hydrogen or alkylcarbonyl; R2 represents alkyl or cycloalkyl; R3 represents phenyl or 3,4-methylenedioxyphenyl, provided that when R3 represents phenyl, the case where R1 represents a group of formula (4) is excluded; R4 represents hydrogen, hydroxyl, R9C(O)O-, R10OCH2O-, -OPO(OH)2 or CH = NOR11; R9 represents alkyl; R10 represents alkyl or alkylcarbonyl; R5 represents hydrogen or CH = NOR11; and R11 represents hydrogen, alkyl or substituted alkyl.
