14733-49-4Relevant academic research and scientific papers
Aminomethylation of acetylene alcohols and their esters with gem-diamines catalyzed by complexes of d-transition and rare-earth metals
Shaibakova,Titova,Ibragimov,Dzhemilev
experimental part, p. 161 - 167 (2011/05/04)
An efficient synthetic procedure was developed for preparation of oxygen-containing propargylamines with high yields and selectivity by aminomethylation of propargyl alcohols and their esters with gem-diamines catalyzed by complexes and salts of d-transit
Mild and efficient synthesis of propargylamines by copper-catalyzed Mannich reaction
Bieber, Lothar W.,Da Silva, Margarete F.
, p. 8281 - 8283 (2007/10/03)
Terminal alkynes can be condensed with aqueous formaldehyde and primary or secondary amines to give secondary and tertiary propargylamines. The reaction is best carried out in DMSO under CuI catalysis. Terminal alkynes undergo mild and efficient aminomethylation with aqueous formaldehyde and secondary amines under CuI catalysis. In most cases high to nearly quantitative yields of tertiary propargylamines are obtained in DMSO solution at room temperature. Aromatic, aliphatic and silylated acetylenes as well as alkynols can be used. Primary amines are less reactive and satisfactory yields of secondary propargylamines are obtained only with phenylacetylene.
Synthesis of dialkyl(4-hydroxy-2-butynyl)amines
Chukhadzhyan,Gevorkyan,Chukhadzhyan,Shakhatuni
, p. 1263 - 1264 (2007/10/03)
2-Propynyl alcohol smoothly reacts with secondary amines and formaldehyde, following the Mannich reaction pattern and yielding the corresponding dialkyl(4-hydroxy-2-butynyl)amines.
