14733-65-4Relevant academic research and scientific papers
Nitriles under palladium-catalyzed hydrogenation conditions as substitutes for aldehydes in the reaction with 1,2-amino alcohols: Formation of 1,3-oxazolidines and reductive N-alkylation
Henin, Francoise,Letinois, Stephane,Muzart, Jacques
, p. 7187 - 7190 (1997)
At room temperature, the presence of hydrogen and catalytic amounts of Pd/C induced the formation of 1,3-oxazolidines from nitriles and 1,2-amino alcohols. The subsequent reductive cleavage of the NC-O bond of these heterocycles occurred under the same conditions. Thus, this methodology provides a new one-pot N-alkylation of 19-amino alcohols using nitriles as reagents with yields up to 98%.
