147332-48-7

Basic information

• Product Name: (4Z)-6-{(2S,4S,5R)-2-[1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl]-4-pyridin-3-yl-1,3-dioxan-5-yl}hex-4-enoic acid
• Synonyms: D1542;D 1542;ZD 1542;ICI D1542
• CAS NO: 147332-48-7
• Molecular Formula: C₂₅H₃₀N₂O₇
• Molecular Weight: 470.5149
• Mol File: 147332-48-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 661.1°C at 760 mmHg
• Flash Point: 353.6°C
• Density: 1.225g/cm³
• Vapor Pressure: 2.22E-18mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (4Z)-6-{(2S,4S,5R)-2-[1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl]-4-pyridin-3-yl-1,3-dioxan-5-yl}hex-4-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4Z)-6-{(2S,4S,5R)-2-[1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl]-4-pyridin-3-yl-1,3-dioxan-5-yl}hex-4-enoic acid(147332-48-7)
• EPA Substance Registry System: (4Z)-6-{(2S,4S,5R)-2-[1-methyl-1-(4-methyl-2-nitrophenoxy)ethyl]-4-pyridin-3-yl-1,3-dioxan-5-yl}hex-4-enoic acid(147332-48-7)

Safety Data

• Hazardous Substances Data: 147332-48-7(Hazardous Substances Data)

Upstream product

• 130205-08-2 2-methyl-2-(2-nitro-4-methylphenoxy)propanal 

Relevant articles and documents

Dual-Acting Thromboxane Receptor Antagonist/Synthase Inhibitors: Synthesis and Biological Properties of alkenoic Acids

The design, synthesis, and pharmacology of a new class of compounds possessing bith thromboxane receptor antagonist and thromboxane synthase inhibitory properties are described.Replacement of the phenol group of the known thromboxane antagonist series 4(Z)-6-hex-4-enoic acid by a 3-pyridyl group led to a series of compounds, 5, which were potent thromboxane synthase inhibitors and weak thromboxane antagonists.Further modifications at the dioxane C2 position led to compounds, 7, which were potent dual-acting agents.In the case of compound 7w, the dual activity was shown to reside almost exclusively in the (-)-enantiomer, 7x.Following oral dosing to rats and dogs, 7x (3 mg/kg) displayed significant dual activity over a period of at least 8 h.