147334-89-2Relevant academic research and scientific papers
Synthetic studies on stevastelins. 1. Total synthesis of stevastelins B and B3
Sarabia, Francisco,Chammaa, Samy
, p. 7846 - 7857 (2007/10/03)
The synthesis of stevastelin B3 (2) and B (5) are described. In a first approach, epoxy cyclodepsipeptide 8 was considered as a promising candidate for the synthesis of the [15]-membered ring members of the stevastelins; however, the oxirane ring opening,
Total synthesis of (-)-stevastelin B
Kurosawa, Kazuo,Nagase, Toshihiko,Chida, Noritaka
, p. 1280 - 1281 (2007/10/03)
The total synthesis and an unambiguous structure confirmation of stevastelin B 1, a novel 15-membered cyclic depsipeptide, are described; the fatty acid moiety in 1, prepared stereoselectively from L-quebrachitol was converted into the amino carboxylic acid, whose macrolactamization by Shioiri's procedure effectively constructed the cyclic structure of 1.
Total synthesis of stevastelin B, a novel immunosuppressant
Kohyama, Naoki,Yamamoto, Yukio
, p. 694 - 696 (2007/10/03)
Total synthesis of stevastelin B is described. Evans asymmetric aldol methodology and Roush asymmetric allylation were used to construct four consecutive stereo-centers on the octadecanoic acid moiety of stevastelin B. Subsequent coupling with a dipeptide
