147366-41-4 Usage
Uses
Used in Cancer Treatment:
MKT 077 is used as an antiproliferative agent for cancer treatment, specifically targeting cancer cells and overcoming tamoxifen resistance. It inhibits the Hsp70 family of molecular chaperones, which play a role in cancer cell proliferation and survival.
Used in Alzheimer's Disease and Tauopathies Treatment:
MKT 077 is used as a therapeutic agent for Alzheimer's disease and other tauopathies, where it may help in addressing the underlying protein misfolding and aggregation issues associated with these conditions.
Used in Drug Delivery Systems:
While not explicitly mentioned in the provided materials, MKT 077's potential application in drug delivery systems could be explored, similar to how gallotannin has been investigated for its use in drug delivery systems to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles could potentially be employed as carriers for MKT 077 delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Biochem/physiol Actions
MKT-077 is an inhibitor of mitochondrial hsp70 family member, mortalin (mot-2)n; causes selective death of cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 147366-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,3,6 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 147366-41:
(8*1)+(7*4)+(6*7)+(5*3)+(4*6)+(3*6)+(2*4)+(1*1)=144
144 % 10 = 4
So 147366-41-4 is a valid CAS Registry Number.
InChI:InChI=1/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;
147366-41-4Relevant academic research and scientific papers
PHARMACEUTICAL COMPOUNDS AND USE OF SAME IN CANCER AND TAUOPATHIES
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Paragraph 0017; 0054, (2014/09/16)
Disclosed are compounds of formula (l)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease (AD). The presence of abnormal tau correlates with neuron loss and memory deficits in patients with AD and other neurodegenerative disorders that involve tau accumulation.
