147372-77-8

Basic information

• Product Name: 1'-[4-(5-Trifluoromethylindazol-3-yl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine]
• CAS NO: 147372-77-8
• Molecular Weight: 429.485
• Mol File: 147372-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1'-[4-(5-Trifluoromethylindazol-3-yl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: 1'-[4-(5-Trifluoromethylindazol-3-yl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine](147372-77-8)
• EPA Substance Registry System: 1'-[4-(5-Trifluoromethylindazol-3-yl)-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine](147372-77-8)

Safety Data

• Hazardous Substances Data: 147372-77-8(Hazardous Substances Data)

Upstream product

• 38309-60-3 3H-spiro[2-benzofuran-1,4'-piperidine] 

Relevant articles and documents

Piperidine derivatives having anxiolytic effect

Piperidine compounds having the general formula (I), STR1 wherein R 1 is a group having general formula (II), STR2 wherein X is CHR 10, O, S, SO, SO 2 or NR 10, Z 1 is CH 2, O, or S; Z 2 and Z 3 are independently (CH 2) n, n being 0 or 1, O or S or Z 1 and Z 2 may together represent a group --CH CH--; or when Z 3 is (CH 2) n wherein n is 0, Z 1 and Z 2 may together represent a 3-membered divalent group; show potent sigma receptor activity. Furthermore they show effect in animal models indicative of anxiolytic properties. Accordingly they are useful as medicines for the treatment of anxiety, psychosis, epilepsy, convulsion, movement disorders, motor disturbances, amnesia, cerebrovascular diseases, senile demential of the Alzheimer type or Parkinson''s disease.