147378-75-4Relevant academic research and scientific papers
NOVEL HETEROCYCLYL COMPOUNDS
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Page/Page column 38, (2010/02/17)
The invention is concerned with novel heterocyclyl compounds of formula (I): wherein A, X, R3, R4, R5, R6, R7, R8, R9, R10, m, n and p are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR2 receptor, CCR5 receptor and/or CCR3 receptor and may be used as medicaments.
Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists
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, (2008/06/13)
Pharmacologically active benzimidazolone derivatives as 5-HT1Aand 5-HT2 receptors, useful in the treatment of CNS disorders of formula: wherein, R1 and R2 may be at the same time or not a hydrogen atom, halogen, trifluoromethyl, C1 6 alkyl, C1 6 alkoxy, C1 6 alkylthio, C1 6 acyl, carboxyl, C1 6 alkoxy- carbonyl, hydroxy, nitro, amino optionally C1 4 alkyl N-mono or di-substituted, C1 6 acylamino, C1 6 alkoxycarbonylamino, carbamoyl optionally C1 4 alkyl N-mono or di-substituted, cyano, C1 6 alkylsulphinyl, C1 6 alkylsulphonyl, amino sulphonyl optionally C1 4 alkyl N-mono or di-substituted, C1 4 alkyl N-mono or di-substituted aminosulphonylamino, aminosulphonylamino;, R3 is hydrogen, C1 6 alkyl, C2 6 alkenyl or C2-C6 alkynyl;, A is -CO- or -CONH- or it is absent;, B is a straight or branched, saturated or unsaturated C2 6 alkyl;, m and n are both independently an integer from 1 to 3;, R4 is an aryl, aralkyl, a heteroaryl or heteroaralkyl group, each group being optionally substituted by one or more substituents selected from halogen, trifluoromethyl, cyano, C1 3 alkoxy, C1 4 alkyland acid addition salts thereof., The process for the preparation of the compounds of formula I as well as pharmaceutical compositions containing them are also described.
