147380-63-0Relevant academic research and scientific papers
ARYLALKYLETHER AND ARYLALKYLTHIOETHER INHIBITORS OF LIPOXYGENASE ENZYME ACTIVITY
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, (2008/06/13)
The present invention provides compounds having the structure Y-Het-[Q1]-X-[Q2 ]-Z which inhibit the catalytic action of lipoxygenase enzymes, particularly 5-lipoxygenase, and thereby reduce the biosynthesis of leukotrienes B4, C4, D4, and E4. In the generic formula given above, X is oxygen or sulfur and Het is a heteroaryl group selected from the group consisting of furyl, thienyl, 2-, 3-, and 4-pyridyl, 2- and 3-benzo[b]furyl, 2- and 3-benzo[b]thienyl and thienothienyl. Y is one or two substituents independently selected from hydrogen, hydroxy, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkoxyaryl), alkylthioaryl, ary-lalkoxy, arylalkylthio, aryloxy, arylthio, alkylamido, cycloalkyl, alkanoyl, alkoxycarbonyl, amino, alkyl-amino, dialkylamino, and the following groups wherein R, at each occurrence, is independently selected from hydrogen and alkyl of from one to six carbon atoms: -CRROR, -NRC(O)R, -NRC(O)OR, and -C-(O)NRR. The group Q1 is absent or is divalent alkylene of from one to six carbon atoms, and Q2 is divalent alkylene from two to ten carbon atoms. The group Z is N(ORi)COR2 where Ri is selected from hydrogen or a pharmaceutically suitable salt. R2 is selected from hydrogen; alkyl; cycloalkyl; amino; alkyl-amino, optionally substituted by hydroxyl, halogen, alkoxy or carboxyl; dialkylamino in which the alkyl groups are independently are optionally substituted by hydroxyl, halogen, alkoxy or carboxyl; cycloalkylamino; 2-hydroxyethylamino; N-morpholino; N-thiomorpholino; N-piperazine; N'-alkyl-N-piperazine and cyclopropylmethylamino.
