147388-83-8 Usage
Uses
Used in Pharmaceutical Industry:
ABT-418 HYDROCHLORIDE is used as an anxiolytic agent for its anxiolytic activity in a rat model, where it was found to be 6-fold more potent than diazepam. This makes it a potential treatment option for anxiety disorders.
Used in Neurological Applications:
ABT-418 HYDROCHLORIDE is used as a cognitive enhancer for its ability to improve cognition in Alzheimer's disease patients. This suggests its potential use in treating cognitive decline associated with neurodegenerative diseases.
Used in Attention Deficit Hyperactivity Disorder (ADHD) Treatment:
ABT-418 HYDROCHLORIDE is used as an attention enhancer for its demonstrated ability to reduce distractibility in a primate model. This indicates its potential relevance in the treatment of ADHD.
Used in Drug Synthesis:
ABT-418 HYDROCHLORIDE is used as a synthetic compound derived from L-proline, which can be further utilized in the development of new drugs targeting neuronal nicotinic acetylcholine receptors for various therapeutic applications.
References
1) Papke et al. (1997), Activation and inhibition of rat neuronal nicotinic receptors by ABT-418; Br. J. Pharmacol., 120 429
2) Brioni et al. (1994), Anxiolytic-like effects of the novel cholinergic channel activator ABT-418; J. Pharmacol. Exp. Therap., 271 353
3) Prendergast et al. (1998), Central nicotinic receptor agonists ABT-418, ABT089, and (-)-nicotine reduce distractibility in adult monkey; Psychopharmacology (Berl), 136 50
4) Beiderman and Spencer (2000), Non-stimulant treatments for ADHD; Eur. Child Adolesc. Psychiatry, 9 Suppl1 151
5) Potter et al. (1999), Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer’s disease; Psychopharmacology (Berl), 142 334
Check Digit Verification of cas no
The CAS Registry Mumber 147388-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,3,8 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 147388-83:
(8*1)+(7*4)+(6*7)+(5*3)+(4*8)+(3*8)+(2*8)+(1*3)=168
168 % 10 = 8
So 147388-83-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H14N2O.ClH/c1-7-6-9(12-10-7)8-4-3-5-11(8)2;/h6,8H,3-5H2,1-2H3;1H/t8-;/m0./s1
147388-83-8Relevant academic research and scientific papers
Elliott,Kopecka,Lin,He,Garvey
, p. 772 - 774 (1995)
A short and efficient synthesis of the novel cholinergic channel activator ABT 418, (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole, has been developed. The four-step route from L-proline afforded the target compound in ca. 35% overall yield in very high chemical and enantiomeric purity. This route has afforded multigram quantities of the clinical candidate and should be amenable to kilogram-scale reactions.
