147397-98-6Relevant academic research and scientific papers
Light-promoted copper-catalyzed cage C-Arylation of: O-carboranes: facile synthesis of 1-Aryl-o-carboranes and o-carborane-fused cyclics
Lu, Zhenpin,Ni, Hangcheng,Xie, Zuowei
supporting information, p. 14944 - 14948 (2021/09/04)
Light-promoted, copper catalyzed cage C-H arylation of o-carboranes with aryl halides has been achieved, leading to the facile synthesis of a variety of 1-Aryl-o-carboranes and o-carborane-fused cyclics. This method has the following features: (1) using o
Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C′-diphenylcarborane scaffold as a hydrophobic pharmacophore
Fujii, Shinya,Yamada, Ayumi,Nakano, Eiichi,Takeuchi, Yuki,Mori, Shuichi,Masuno, Hiroyuki,Kagechika, Hiroyuki
, p. 264 - 277 (2014/08/05)
The progesterone receptor (PR) plays important roles in multiple physiological processes, including female reproduction. Here, we report the synthesis of nonsteroidal PR antagonists containing a boron cluster as the hydrophobic core. We found that 1,7-diphenyl-meta-carborane was the preferred substructure among the three carborane isomers. Compound 39 was the most potent PR antagonist (IC50: 29 nM). Compound 41 also exhibited potent activity (IC50: 93 nM), and did not bind to androgen receptor, glucocorticoid receptor or mineralocorticoid receptor. These compounds may be useful for investigating potential clinical applications of PR modulators.
Labelling of carbaboranyl compounds with a selenium atom with a view to applications in boron-neutron-capture therapy (BNCT) and positron-emission tomography (PET)
Dos Santos, Deborah F.,Argentini, Mario,Weinreich, Regin,Hansen, Hans-Juergen
, p. 2926 - 2938 (2007/10/03)
We synthesized 2′-carbaboranyl-2.5′-bi-1H-benzimidazoles containing 10 B-atoms and labeled with Se or the positron-emitting radionuclide 73Se (I1/2=7.1 h). with a view to their application to cancer treatment by boron-neutron-capture
