147404-76-0

Basic information

• Product Name: Azilsartan iMpurity A
• Synonyms: Azilsartan iMpurity A;Methyl 1-((2'-carboxaMidebiphenyl-4-yl) Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylate;ethyl 1-((2'-carboxaMidebiphenyl-4-yl) Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylate;1-((2'-carboxaMidebiphenyl-4-yl) Methyl)-2-ethoxy-1H-benziMidazole-7- carboxylic acid;Methyl 1-[((2'-(2,5-dihydro-5-oxo-1,2,4- xadiazol-3-yl)biphenyl)-4-yl)Methyl]-2H-benziMidazol-2-one -7- carboxylate;Ethyl 1-[((2'-(2,5-dihydro-5-oxo-1,2,4- xadiazol-3-yl)biphenyl)-4-yl)Methyl]-2H-benziMidazol-2-one -7- carboxylate;1-[[2'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester;methyl 1-((2'-carbamoyl-[1,1'-biphenyl] -4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate
• CAS NO: 147404-76-0
• Molecular Formula: C₂₅H₂₃N₃O₄
• Molecular Weight: 429.46782
• Mol File: 147404-76-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 652.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 15.84±0.50(Predicted)
• CAS DataBase Reference: Azilsartan iMpurity A(CAS DataBase Reference)
• NIST Chemistry Reference: Azilsartan iMpurity A(147404-76-0)
• EPA Substance Registry System: Azilsartan iMpurity A(147404-76-0)

Safety Data

• Hazardous Substances Data: 147404-76-0(Hazardous Substances Data)

Usage

General Description

Azilsartan iMpurity A is a chemical compound that acts as an impurity in the production of the drug azilsartan, which is used to treat high blood pressure. The impurity has the potential to affect the quality and efficacy of the final drug product and needs to be carefully monitored and controlled during the manufacturing process. Azilsartan iMpurity A can be formed during the synthesis of azilsartan and needs to be accurately identified and quantified to ensure the safety and effectiveness of the medication. Regulatory authorities have set specific limits on the presence of this impurity in the final drug product to ensure its safety for human consumption. Therefore, strict quality control measures need to be in place in the production of azilsartan to prevent the formation and accumulation of this impurity.

Upstream product

• 147403-65-4 methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 139481-44-0 methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate 

Downstream Products

• 1696392-11-6 1-((2’-carbamoyl-[1,1’-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid 

Relevant articles and documents

A process for the preparation of intermediates arab League Qi Shatan

The invention discloses a preparation method of an azilsartan intermediate. The preparation method of the azilsartan intermediate comprises the following steps: dissociating hydroxylamine hydrochloride through alkali in ethanol which is 90-95% in mass percentage, filtering, adding a compound as shown in formula (II) in the specification, triethylamine and ethanol to filtrate, implementing a reflux reaction, cooling and crystallizing after the reaction, and filtering to obtain the target intermediate as shown in formula (I). The target intermediate prepared by the preparation method disclosed by the invention is high in content, and low in content of amide impurities, which is generally less than 10%.

Aitch sand smooth intermediate and its preparation method (by machine translation)

The invention discloses Aitch sand smooth intermediate and its preparation method. The preparation method comprises the following steps: in the solvent, compound 2B with hydroxylamine mixing, reaction, get compound 3B can be. The invention method for preparing the Aitch of less impurity, short reaction time, the higher process yield, high purity of the product, is suitable for industrial production. (by machine translation)