1474040-00-0Relevant academic research and scientific papers
A facile and practical synthesis of Nicolaou's key intermediates, 2-methyl- and 2,6-dimethyltetrahydropyrans, toward the total synthesis of ladder-shaped polyethers
Nakashima, Takeharu,Baba, Tomomi,Onoue, Hisaaki,Yamashita, Wataru,Torikai, Kohei
, p. 2417 - 2425 (2013/09/23)
A facile and robust method to prepare 2-methyl- and 2,6- dimethyltetrahydropyrans, most useful Nicolaou intermediates for the synthesis of ladder-shaped polyethers, is disclosed. The established highly practical recipe, adopting chemo- and stereoselective catalytic oxidations and one-pot reactions with few chromatographic purifications, would significantly facilitate the large-scale supply of pivotal monocyclic building blocks, which is a rate-determining process of gigantic tetrahydropyran-containing natural products synthesis.
