1474058-89-3

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-2-(4-vinylphenoxy)propionic acid is used as an impurity in the production of Ciprofibrate, which serves as an antilipemic agent. Its presence, although as an impurity, may have implications for the overall efficacy and safety profile of the drug, making it a relevant compound to study and understand in the context of hypolipidemic therapy.
Additionally, given its unique chemical structure, 2-methyl-2-(4-vinylphenoxy)propionic acid could potentially be explored for other applications within the pharmaceutical industry, such as in the development of new drugs or drug delivery systems, due to its vinyl group which may allow for further chemical modifications and interactions with biological targets.

Upstream product

• 2628-17-3 4-Vinylphenol 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant academic research and scientific papers

Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice

Peroxisome proliferator-activated receptors are promising therapeutic targets for metabolic diseases, including obesity, diabetes, and dyslipidemia. This study describes the design, synthesis and pharmacological evaluation of stilbene-based compounds as d

Synthetic method of lipid-lowering drug ciprofibrate

The invention provides a synthetic method of lipid-lowering drug ciprofibrate. The synthetic method comprises the following steps: catalyzing reaction of p-hydroxy benzaldehyde and propane diacid in a mixed solvent by virtue of alkali, so as to generate p-hydroxystyrene; catalyzing reaction of p-hydroxystyrene, acetone, chloroform and alkali by virtue of a phase transfer catalyst, so as to generate an intermediate 2-methyl-2-(4-vinylphenoxy)propionic acid; and reacting 2-methyl-2-(4-vinylphenoxy)propionic acid with TiCl4, Mg and CCl4, so as to generate ciprofibrate. The synthetic method has the beneficial effects that the reaction route is short, the raw materials are cheap and easily available, reaction conditions are mild, the energy consumption is reduced, and the production cost is lowered; the post-processing step is simple, the emission of three wastes is reduced, and the method is environment-friendly and safe. Compared with routes of predecessors, the synthetic method has the advantages that the reaction selectivity and conversion rate of the route are relatively high, the wasting of the raw materials is reduced, and the economical efficiency is relatively high.