1474060-40-6Relevant academic research and scientific papers
Rhodium(III)-catalyzed C-H activation mediated synthesis of isoquinolones from amides and cyclopropenes
Hyster, Todd K.,Rovis, Tomislav
, p. 1842 - 1844 (2013)
We have developed a synthesis of 4-substituted isoquinolones from the rhodium(III)-catalyzed, C-H activation mediated coupling of O-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic system, which can open under acidic conditions to generate the desired isoquinolone. Georg Thieme Verlag Stuttgart · New York.
