147495-99-6Relevant articles and documents
SUBSTITUTED 3,4-DIHYDRONAPHTHALENES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PREPARATION PROCESSES
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, (2008/06/13)
Substituted 3,4-dihydronaphthalenes of the formula I wherein R1 is a methyl or an amino group, R2 represents a hydrogen atom or a methyl group, and R3 is a linear or branched chain alkyl residue having 1 to 4 carbon atoms, an allyl or a crotyl group or a cyclopentyl group are disclosed which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of disorders attributable to the action of leucotrienes. The dihydronaphthalenes may be prepared by reacting a compound of formula II. with hydroxylamine or a salt thereof to form the corresponding oxime, reducing the oxime to a hydroxylamine of formula III and introducing a -CO-R1 group.