147497-53-8

Basic information

• Product Name: BenzaMide, 4-Methoxy-N-(3-phenylpropyl)-
• Synonyms: BenzaMide, 4-Methoxy-N-(3-phenylpropyl)-
• CAS NO: 147497-53-8
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.33826
• Mol File: 147497-53-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzaMide, 4-Methoxy-N-(3-phenylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 4-Methoxy-N-(3-phenylpropyl)-(147497-53-8)
• EPA Substance Registry System: BenzaMide, 4-Methoxy-N-(3-phenylpropyl)-(147497-53-8)

Safety Data

• Hazardous Substances Data: 147497-53-8(Hazardous Substances Data)

Upstream product

• 2038-57-5 3-Phenylpropan-1-amine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 645-59-0 dihydrocinnamonitrile 
• 105-13-5 4-Methoxybenzyl alcohol 
• 1202354-81-1 C₁₇H₁₉NO₂ 

Relevant articles and documents

Method for preparing amide compounds through ionic liquid catalysis in high-pressure environment

The invention relates to a method for preparing amide compounds through ionic liquid catalysis in a high-pressure environment. According to the method, ionic liquid 1-ethyl-3-methylimidazolium acetateis used as a catalyst and a solvent, oxygen is used as an oxidizing agent, and aromatic methanol or alkyl alcohol is converted into an amide compound under the conditions of high pressure and heating. The synthesis method provided by the invention has the advantages that the raw material and technical cost is low; compared with other traditional methods, the method is safe, low in toxicity, economical and environmentally friendly; and the method has few steps, is simple and convenient to operate, is beneficial to large-scale synthesis, and has important significance for synthesis of amide compounds and large-scale industrialization of preparation.

Method for preparation of amide and imide from alcohol and nitrogen Containing Compound

The present invention relates to a method for preparing amide and imide from alcohol and a nitrogen containing compound and, more specifically, to a method for preparing amide and imide by using: a catalytic composition obtained by reacting a mixture of a transition metal complex and an N-heterocyclic carbene precursor with base or by reacting an N-heterocyclic carbene precursor with a mixture of a transition metal complex and base; or a transition metal complex catalyst including an N-heterocyclic carbene.

Aryl amide small-molecule inhibitors of microRNA miR-21 function

MicroRNAs (miRNAs) are single stranded RNA molecules of ～22 nucleotides that negatively regulate gene expression. MiRNAs are involved in fundamental cellular processes, such as development, differentiation, proliferation, and survival. MiRNA misregulation has been linked to various human diseases, most notably cancer. MicroRNA-21 (miR-21), a well-established oncomiR, is significantly overexpressed in many types of human cancers, thus rendering miR-21 a potential therapeutic target. Using a luciferase-based reporter assay under the control of miR-21 expression, a high-throughput screen of >300,000 compounds led to the discovery of a new aryl amide class of small-molecule miR-21 inhibitors. Structure-activity relationship (SAR) studies resulted in the development of four aryl amide derivatives as potent and selective miR-21 inhibitors. The intracellular levels of various miRNAs in HeLa cells were analyzed by qRT-PCR revealing specificity for miR-21 inhibition over other miRNAs. Additionally, preliminary mechanism of action studies propose a different mode of action compared to previously reported miR-21 inhibitors, thus affording a new chemical probe for future studies.