14750-19-7

Basic information

• Product Name: ethyl 3-methyl-2-oxo-3-indolinecarboxylate
• Synonyms: ethyl 3-methyl-2-oxo-3-indolinecarboxylate
• CAS NO: 14750-19-7
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.23652
• Mol File: 14750-19-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 3-methyl-2-oxo-3-indolinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-methyl-2-oxo-3-indolinecarboxylate(14750-19-7)
• EPA Substance Registry System: ethyl 3-methyl-2-oxo-3-indolinecarboxylate(14750-19-7)

Safety Data

• Hazardous Substances Data: 14750-19-7(Hazardous Substances Data)

Upstream product

• 26304-51-8 ethyl 3-methyl-indole-2-carboxylate 
• 10565-14-7 Diethyl 2-(2-nitrophenyl)propanedioate 
• 71127-36-1 diethyl methyl(2-nitrophenyl)malonate 

Relevant articles and documents

Reaction of ethyl acylindole-2-carboxylates with thallium trinitrate (synthetic studies on indoles and related compounds. XXXIII)

Ethyl acylindole-2-carboxylates were treated with thallium trinitrate (TTN) in methanol, methyl orthoformate, methyl orthoformate/sulfuric acid, and acetic acid. The reactions in the former three methanolic solvents gave methyl indoleacetate derivatives via the Favorskii-type rearrangement reaction at the acyl group, whereas the reaction in acetic acid gave oxindole derivative with rearrangement of the C2-ethoxycarbonyl group. The TTN reaction was applied to a model compound leading to the synthesis of lysergic acid.

Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor

A facile method to construct quaternary 3,3-disubstituted 2-oxindole from 2-substituted indole without a catalyst in mild conditions is developed. A mechanistic study suggests that an iminium-intermediate-triggered 1,2-rearrangement is involved, and a tra