147527-10-4

Upstream product

• 944353-04-2 (5S,6R)-6-((1R,2S)-1,2-bis(methoxymethoxy)-2-phenylethyl)-5-(benzyloxy)-5,6-dihydropyran-2-one 
• 1006371-24-9 (5S,6R)-6-[(4R,5S)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-5-(methoxymethoxy)-5,6-dihydro-2H-pyran-2-one 
• 153359-62-7 (S)-((4S,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-furan-2-yl-methanol 
• 252273-56-6 ethyl (2S,3R,4S)-4-hydroxy-2,3-isopropylidenedioxy-4-phenylbutanoate 
• 252273-54-4 ethyl (2S,3R,4R)-4-hydroxy-2,3-isopropylidenedioxy-4-phenylbutanoate 
• 252273-58-8 trimethyl [5S,6S,7S]-7-(t-butyldiphenylsilyloxy)-5,6-isopropylidenedioxy-4-oxo-7-phenyl-3-phenylsulfonylorthoheptanoate 
• 252273-57-7 ethyl (2S,3R,4S)-4-(t-butyldiphenylsilyloxy)-2,3-isopropylidenedioxy-4-phenylbutanoate 
• 252273-55-5 ethyl (2S,3R,4S)-2,3-isopropylidenedioxy-4-(4-nitrobenzyloxy)-4-phenylbutanoate 
• 187931-99-3 ethyl (4S,5S)-5-[(R)-{[(tert-butyl)(dimethyl)silyl]oxy}(phenyl)methyl]-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 221108-28-7 (4R,5S)-2,2-dimethyl-4-(2-furoyl)-5-phenyl-1,3-dioxolane 
• 1054624-97-3 (S)-6-((4R,5S)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-pyran-2,5-dione 
• 153359-64-9 (5S,6R)-5-hydroxy-6-<(1R,2S)-1,2-isopropylidenedioxy-2-phenylethyl>-5,6-dihydropyran-2-one 
• 148162-42-9 4,6-O-Isopropylidene-7-C-phenyl-L-ido-hept-2-enono-δ-lactone 
• 148162-41-8 (Z)-Methyl 4,6-O-isopropylidene-7-C-phenyl-L-ido-hept-2-enonate 

Relevant academic research and scientific papers

Synthesis of (+)-goniopypyrone and (+)-goniotriol using Pd-catalyzed carbonylation

Syntheses of (+)-goniopypyrone and (+)-goniotriol isolated from Goniothalamus giganteus were achieved. The key steps involve Pd-catalyzed carbonylation for lactone ring formation and diastereoselective reduction of ynone using the (R)-CBS catalyst and borane dimethyl sulfide complex.

Stereoselective total synthesis of bioactive styryllactones (+)-goniofufurone, (+)7-epi-goniofufurone, (+)-goniopypyrone, (+)-goniotriol, (+)-altholactone, and (-)etharvensin

(Chemical Equation Presented) Stereoselective total synthesis of biologically active styryllactones 7-epi-goniofufurone, goniofufurone, goniopypyrone, goniotriol, altholactone, and etharvensin was achieved in high overall yields from a common intermediate

Stereoselective total synthesis of bioactive styryllactones: 9-Deoxygoniopypyrone, goniopypyrone and 7-epi-goniofufurone

Stereoselective synthesis of the bioactive styryllactones (+)-9-deoxygoniopypyrone, (+)-goniopypyrone and (+)-7-epi-goniofufurone has been achieved from D-(-)-tartaric acid. The key step involves the elaboration of a trihydroxy ester to the title compound

Julia-Colonna asymmetric epoxidation of furyl styryl ketone as a route to intermediates to naturally-occurring styryl lactones

The enone 1 was oxidized stereoselectively using urea-hydrogen peroxide with polyleucine as the catalyst to give the epoxide 2 which was used to make (+)-goniotriol 7, (+)-goniofufurone 8, (+)-8-acetylgoniotriol 9 and goniopypyrone 10.

Total synthesis of antitumor agents, (+)-goniopypyrone and (+)-7-epi-goniofufurone

Synthesis of enantiopure (+)-7-epi-goniofufurone 1 and (+)-goniopypyrone 2 has been achieved from C-4 carbon chain chiron 3, readily available from (R)-mandelic acid.

Enantiospecific Syntheses of (+)-Goniofufurone, (+)-7-epi-Goniofufurone, (+)-Goniobutenolide A, (-)-Goniobutenolide B, (+)-Goniopypyrone, (+)-Altholactone, (+)-Goniotriol, and (+)-7-Acetylgoniotriol

Practical and efficient syntheses of a number of styryl lactones with various structural complexities were accomplished from commercially available and inexpensive D-glycero-D-gulo-heptono-γ-lactone (D-glucoheptonic γ-lactone) (11).Lactone 11 was converte

A Convenient Enantioselective Synthesis of (+)-8-epi-Goniofufurone

A convenient synthesis of (+)-8-epi-goniofufurone from methyl cinnamate has been completed.A key step is the intramolecular double cyclisation reaction.

FIRST TOTAL SYNTHESIS OF POTENT ANTITUMOUR AGENT (+)-GONIOPYPYRONE

The structure and absolute stereochemistry of the natural goniopypyrone is confirmed as 1 by a short and stereoselective synthesis in nine steps from D-glycero-D-gulo-heptono-γ-lactone with an overall yield of 9.7 percent.