14753-26-5Relevant articles and documents
A Facile Strategy for the Construction of Cyclic Peptoids under Microwave Irradiation through a Simple Substitution Reaction
Kaniraj, Prathap Jeya,Maayan
, p. 2110 - 2113 (2015)
We describe a fast and efficient side chain-to-tail cyclization of N-substituted glycine oligomers, peptoids, on a solid support and under microwave irradiation. We demonstrate that cyclic peptoids varied in their ring size and side chains can be synthesized by a bond formation between a chloropropyl group placed anywhere along the sequence and the secondary amine at the N-terminus. This SN2 reaction leads to the formation of a new C-N bond using only one reagent (a base). (Chemical Equation Presented).
Facile method for the synthesis of triazole- and tetrazole-containing peptoids on a solid support
Lee, Yen Jea,Kang, Dahyun,Seo, Jiwon
, p. 3311 - 3316 (2018)
The late-stage functionalization of a biomimetic foldamer such as a peptoid is a useful tool to achieve structural diversity. Herein, a facile method for the synthesis of triazole- or tetrazole-containing peptoids using post-synthetic modifications has been reported. On a resin-bound peptoid with a chloroalkyl side chain(s), substitution with nucleophiles (azide or cyanide) and the subsequent [3 + 2]-cycloaddition reaction were optimized. Peptoids with azide, triazole, and tetrazole functional groups could be readily synthesized and could potentially be utilized further for orthogonal bioconjugation or metal recognition.
Copper (II) complexes with tetradentate N4 and N2S2 ligands: effect of ligands on redox behavior and EPR parameters. Superoxide dismutase-like activity
Chautemps, Pierre,Gellon, Gisele,Morin, Benedicte,Pierre, Jean-Louis,Provent, Christophe,et al.
, p. 434 - 443 (2007/10/02)
Nine copper (II) complexes with tetradentate N4 and N2S2 (open chain or macrocyclic) ligands were prepared and studied in solution.For comparison, one N2O2 and one N3S ligand were included.EPR studies evidenced the stereochemistry around the copper (II) ion (square planar or tetrahedrally distorted).The redox or reduction potentials were obtained from electrochemical studies.UV-visible spectra gave additional information on the stereochemistry of the complexes and the deprotonation of amide ligands.The effect of ligands on redox behavior and stereochemistry is dicussed.Superoxide dismutase (SOD) activities were evidenced for the 11 complexes by spin-trapping method and by NBT assay.Unfortunately, the SOD activities do not survive bovine serum albumin in solution. - Keywords: Cu (II) complexes; EPR spectroscopy; electrochemistry; UV-visible spectroscopy; superoxide dismutase activity.