147531-47-3

Basic information

• Product Name: 2-(IsopropylaMino)benzonitrile
• Synonyms: 2-(IsopropylaMino)benzonitrile
• CAS NO: 147531-47-3
• Molecular Formula: C₁₀H₁₂N₂
• Molecular Weight: 160.21568
• Mol File: 147531-47-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(IsopropylaMino)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(IsopropylaMino)benzonitrile(147531-47-3)
• EPA Substance Registry System: 2-(IsopropylaMino)benzonitrile(147531-47-3)

Safety Data

• Hazardous Substances Data: 147531-47-3(Hazardous Substances Data)

Usage

General Description

2-(Isopropylamino)benzonitrile is a chemical compound with the formula C10H13N. It is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. It is a white solid that is soluble in organic solvents. 2-(IsopropylaMino)benzonitrile is often employed as an intermediate in the production of various drugs and is considered an important precursor in the pharmaceutical industry. It is also used in research and development of new compounds due to its versatile reactivity and functional group properties.

Upstream product

• 24642-83-9 N-isopropyl-N-phenylnitrous amide 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 4387-36-4 2-iodobenzonitrile 
• 75-31-0 isopropylamine 
• 394-47-8 2-fluorobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 116-11-0 2-Methoxypropene 

Downstream Products

• 938-16-9 2,2-dimethylpropiophenone 
• 1448622-36-3 C₁₆H₂₆OSi 
• 1448622-37-4 C₁₉H₃₂OSi 
• 1448622-33-0 1-(2-isopropylaminophenyl)-2,2-dimethyl-1-propanone 
• 147531-51-9 2-[(Diphenyl-phosphinoylmethyl)-isopropyl-amino]-benzonitrile 

Relevant articles and documents

Reductive alkylation of aromatic amines with enol ethers

Reductive alkylation of aromatic amines with 2-methoxypropene using 1.0 equivalent of HOAc and NaBH(OAc)3 in 1,2-dichloroethane (DCE) at room temperature furnished N-isopropyl amines in 50-98% yields. This method was successfully extended to trimethylsilyl enol ethers. The mild reaction conditions provide a new alternative procedure for the reductive amination of electron deficient aromatic amines.

Ruthenium-catalyzed reductive deamination and tandem alkylation of aniline derivatives

We developed two new catalytic transformations of anilines via oxidative addition of CeN bonds to ruthenium centers. One is ruthenium-catalyzed reductive deaminatoindeamination of N-alkylated oacylanilines. The other one is catalytic coupling of N-alkylated o-acylanilines with olefins giving orthoalkylated aromatic ketones via CeN bond cleavage. This reaction involves a ruthenium hydride species as an intermediate, formed after b-hydride elimination from the ruthenium amide species.

Imidazoquinazoline derivatives

PCT No. PCT/JP97/03023 Sec. 371 Date Apr. 27, 1998 Sec. 102(e) Date Apr. 27, 1998 PCT Filed Aug. 29, 1997 PCT Pub. No. WO98/08848 PCT Pub. Date Mar. 5, 1998Imidazoquinoline derivatives of the formula (wherein X may be O or S) provide selective cyclic guanosine 3',5' monophosphate (cGMP)-specific phosphodiesterase (PDE) inhibitory activity. The compounds are useful for treating or ameliorating cardiovascular disease such as thrombosis, angina pectoris, hypertension, heart failure and arterial sclerosis, as well as asthma, impotence and the like.