147538-72-5Relevant academic research and scientific papers
Derivatives of (hetero)aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
A compound represented by the following formula I: wherein: (HET)Ar represents a bicyclic hetero aryl nucleus which is unsubstituted or is substituted; X represents --S--; Y represents --CO--, --C=N--R2, in which R2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, --NH2, --NHCONH2, --NHCSNH2 ; and R represents a phenyl substituted at para position with a carboxyl or a (C1 -C20) alkoxycarbonyl group in which the alkoxy group is linear or branched.
Derivatives of (hetero) aromatic ethers and thioethers having antihyperlipidemic activity, process for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The novel derivatives of (hetero)aromatic ethers and thioethers represented by the following general formula I:, , (HET)Ar-X-CH2-Y-CH2-O-R (I), , wherein:, (HET)Ar represent a mono-,bi- and tri-cyclic aryl or hetero aryl nucleous possibly substituted, X represents -O- or -S-;, Y represents -CO-, a linear or branched polymethylene having 0 to 8 carbon atoms with the proviso that it is not (CH2)nin which 01), in which R1 is hydrogen or an acyl group deriving from an aliphatic, aromatic or heterocyclic carboxylic acid, provided that R1 is not hydrogen when (HET)Ar represents a guanine, adenine or adenosine group, -C=N-R2, in which R2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, -NH2, -NHCONH2, -NHCSNH2; and R represents a phenyl substituted at para position with a carboxyl or a (C1-C20) alkoxycarbonyl group in which the alkoxy group may be linear or branched, are endowed with antihyperlipidemic activity. There are furthermore described the process for their preparation and the pharmaceutical compositions containing them.
