147539-61-5

Basic information

• Product Name: Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI)
• Synonyms: Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI);1,2,6-TriMethyl piperazine;(2R,6S)-rel-1,2,6-TriMethylpiperazine;cis-1,2,6-trimethylpiperazine;(2S,6R)-1,2,6-trimethylpiperazine;(2R,6S)-1,2,6-Trimethylpiperazine
• CAS NO: 147539-61-5
• Molecular Formula: C₇H₁₆N₂
• Molecular Weight: 128.22
• EINECS: 201-402-2
• Product Categories: AMINETERTIARY;PIPERAZINE
• Mol File: 147539-61-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 154.0±8.0 °C(Predicted)
• Appearance: /
• Density: 0.835±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.48±0.10(Predicted)
• CAS DataBase Reference: Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI)(147539-61-5)
• EPA Substance Registry System: Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI)(147539-61-5)

Safety Data

• RIDADR: UN1760
• Hazardous Substances Data: 147539-61-5(Hazardous Substances Data)

Usage

General Description

Piperazine, 1,2,6-trimethyl-, (2R,6S)-rel- (9CI) is a chemical compound that belongs to the class of organic compounds known as 1,2-dialkylpiperazines. These are piperazine rings where the nitrogen atoms are both substituted by alkyl groups. It has not been widely studied, thus detailed information about its properties and potential applications is limited. Like other piperazines, it may be used in medicinal chemistry — but its exact uses and properties would need to be determined by specific scientific study. The exact safety, health effects, and environmental impacts of this chemical are also not well-established.

Upstream product

• 21655-48-1 cis-2,6-dimethylpiperazine 
• 1152111-15-3 tert-butyl cis-3,4,5-trimethylpiperazine-1-carboxylate 
• 129779-30-2 (3S,5R)-3,5-dimethylpiperazine-1-carboxylic acid tert-butyl ester 
• 50-00-0 formaldehyd 
• 1152111-14-2 tert-butyl cis-3,5-dimethylpiperazine-1-carboxylate 
• 63207-08-9 3r,5c-dimethyl-piperazine-1-carboxylic acid ethyl ester 

Downstream Products

• 1035270-10-0 N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-5-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyrazine-2-carboxamide 
• 1035270-15-5 N-[5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-yl]-5-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]pyrazine-2-carboxamide 
• 1258305-26-8 5-[2-ethoxy-5-((3,4,5-trimethylpiperazin-1-yl)-sulfonyl)phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one 

Relevant articles and documents

BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION

The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto- temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

COMPOUND FOR INHIBITING TYPE 5 PHOSPHODIESTERASE AND PREPARATION METHOD THEREOF

The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis.