147541-01-3 Usage
Uses
Used in Organic Synthesis:
N-FLUORO-4,6-DIMETHYLPYRIDINIUM-2-SULFONATE is utilized as a fluorinating agent for introducing fluorine atoms into organic molecules. Its application is crucial in enhancing the reactivity and stability of the resulting compounds, which is particularly important in the synthesis of pharmaceuticals and agrochemicals.
Used in Pharmaceutical Production:
In the pharmaceutical industry, N-FLUORO-4,6-DIMETHYLPYRIDINIUM-2-SULFONATE serves as a key reagent for the synthesis of fluorine-containing drugs. The incorporation of fluorine atoms can significantly alter the pharmacokinetic and pharmacodynamic properties of these drugs, potentially leading to improved therapeutic effects and reduced side effects.
Used in Agrochemical Production:
Similarly, in agrochemicals, N-FLUORO-4,6-DIMETHYLPYRIDINIUM-2-SULFONATE is used as a fluorinating agent to create molecules with enhanced pesticidal activity. The introduction of fluorine can improve the lipophilicity and metabolic stability of agrochemicals, thereby increasing their effectiveness and reducing environmental impact.
Used in Material Science:
N-FLUORO-4,6-DIMETHYLPYRIDINIUM-2-SULFONATE is also employed in the development of materials with specific properties conferred by fluorine-containing functionalities. These materials can be used in various high-tech applications, such as in the production of advanced polymers, coatings, and electronic components.
Check Digit Verification of cas no
The CAS Registry Mumber 147541-01-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,5,4 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 147541-01:
(8*1)+(7*4)+(6*7)+(5*5)+(4*4)+(3*1)+(2*0)+(1*1)=123
123 % 10 = 3
So 147541-01-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FNO3S/c1-5-3-6(2)9(8)7(4-5)13(10,11)12/h3-4H,1-2H3
147541-01-3Relevant academic research and scientific papers
Highly Selective Fluorinating Agents: A Counteranion-Bound N-Fluoropyridinium Salt System
Umemoto, Teruo,Tomizawa, Ginjiro
, p. 6563 - 6570 (2007/10/03)
A series of alkyl- or (trifluoromethyl)-substituted N-fluoropyridinium-2-sulfonates 2a-h, differing in fluotinating power, were synthesized, and assessment was made of the effectiveness of each selective fluorinating agent.N-Fluoropyridinium-3- and -4-sulfonates 3 and 4 were also synthesized.Power-variables 2a-h were found to be highly selective fluorinating agents for a wide range of nucleophilic substrates such as activated aromatics, enol trialkylsilyl and alkyl ethers, active methylene compounds, activated olefins, and sulfides.Thus, phenol, naphthol, phenylurethane, and the trimethylsilyl ether of phenol were exclusively or highly selectively fluorinated at the o-position with 2f-h.Conjugated enol trialkylsilyl ethers of a steroid were regioselectively fluorinated at the 6-position with moderately powerful 2b-e.This regioselectivity increased with the bulkiness of the silyl part, and with the most bulky triisopropylsilyl group exclusive 6-fluorination was achieved.Preferential β-stereoselective fluorination at the 6-position was observed.N-Fluoropyridinium-2-sulfonates were activated with an acid.This acid-catalyzed fluorination led to the preferential p-fluorination of anisole.The present results can be explained based on the capacity of the 2-sulfonate anion to interact with the hydroxy group of phenol or naphthol, NH group of phenylurethane, silicon atoms of silyl ethers, or protons of acids.
Certain substituted N-fluoropyridiniumsulfonates
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, (2008/06/13)
A substituted N-fluoropyridiniumsulfonate of the formula: STR1 in which R1 is a hydrogen atom, a halogen atom or a C1 -C4 alkyl or haloalkyl group, and R2 is a C1 -C4 alkyl or haloalkyl group, which is an effective fluorinating agent.
