147577-25-1Relevant articles and documents
Chemical Synthesis of Modified Hyaluronic Acid Disaccharides
Mende, Marco,Nieger, Martin,Br?se, Stefan
supporting information, p. 12283 - 12296 (2017/09/14)
Herein we report a chemical synthesis towards new modified hyaluronic acid oligomers by using only commercially available d-glucose and d-glucosamine hydrochloride. The various protected hyaluronic acid disaccharides were synthesized bearing new functional groups at C-6 of the β-d-glucuronic acid moiety with a view to structure-related biological activity tests. The orthogonal protecting group pattern allows ready access to the corresponding higher oligomers. Also, 1H NMR studies of the new derivatives demonstrated the effect of the various functional groups on the intramolecular electronic environment.