147589-46-6

Basic information

• Product Name: ethyl 6-chloro-4-hydroxy-5,8-dimethoxynaphthalene-2-carboxylate
• Synonyms: ethyl 6-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate; Ethyl-6-chlor-4-hydroxy-5,8-dimethoxy-2-naphthoat
• CAS NO: 147589-46-6
• Molecular Formula: C₁₅H₁₅ClO₅
• Molecular Weight: 310.7296
• Mol File: 147589-46-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 498.149°C at 760 mmHg
• Flash Point: 255.072°C
• Density: 1.315g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: ethyl 6-chloro-4-hydroxy-5,8-dimethoxynaphthalene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-chloro-4-hydroxy-5,8-dimethoxynaphthalene-2-carboxylate(147589-46-6)
• EPA Substance Registry System: ethyl 6-chloro-4-hydroxy-5,8-dimethoxynaphthalene-2-carboxylate(147589-46-6)

Safety Data

• Hazardous Substances Data: 147589-46-6(Hazardous Substances Data)

Upstream product

• 90064-48-5 4-chloro-2,5-dimethoxybenzaldehyde 
• 124010-11-3 Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate 

Relevant articles and documents

Synthesis of pluraflavin A "aglycone"

The "aglycone" of pluraflavin A (2) has been synthesized. The key features of this synthesis include a 1,3-dipolar cycloaddition between a nitrile oxide (cf. 14) and an olefin (22) to yield an isoxazoline followed by subsequent conversion into the γ-pyrone of pluraflavin A. The epoxide moiety linked to the pyrone is installed prior to Diels-Alder installation of the D ring, which allows access to a number of potentially active cytotoxic intermediates en route to the final compound. The preliminary in vitro results of two such compounds are also included with the racemic title compound exhibiting cytotoxicity in the nanomolar range.