14759-46-7

Basic information

• Product Name: Methanone, phenyl(2-phenyl-1-indolizinyl)-
• CAS NO: 14759-46-7
• Molecular Formula: C21H15NO
• Molecular Weight: 297.356
• Mol File: 14759-46-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl(2-phenyl-1-indolizinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl(2-phenyl-1-indolizinyl)-(14759-46-7)
• EPA Substance Registry System: Methanone, phenyl(2-phenyl-1-indolizinyl)-(14759-46-7)

Safety Data

• Hazardous Substances Data: 14759-46-7(Hazardous Substances Data)

Upstream product

• 13141-42-9 2-(2-phenylethynyl)pyridine 
• 70-11-1 α-bromoacetophenone 
• 110-86-1 pyridine 
• 6266-23-5 1-(carboxymethyl)pyridinium chloride 
• 94-41-7 benzalacetophenone 
• 96206-86-9 1-(2-Oxo-2-phenyl-ethyl)-2-phenylethynyl-pyridinium; bromide 

Relevant articles and documents

Synthesis of indolizine derivatives with selective antibacterial activity against Mycobacterium tuberculosis

1-Substituted indolizines with activity against Mycobacterium tuberculosis have been synthesized. The most active compounds carry an hydroxyphenylmethyl- or hydroxyalkyl substituent in the indolizine 1-position. The alkyl chain should be moderately long (C-5 or C-6). Aryl groups in the 2- and 3-position of the indolizine are also required. Removal of the 3-substituent resulted in significant loss of activity. A nitrile substituent in the 7-position is beneficial for both chemical stability and bioactivity. The compounds studied display a narrow antibacterial spectrum and appear to be quite selective antimycobacterial compounds. Moderate activity against certain pathogenic protozoa was also observed.