147591-46-6 Usage
Description
ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2
Uses
ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.
General Description
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Biochem/physiol Actions
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
References
1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242
2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18
Check Digit Verification of cas no
The CAS Registry Mumber 147591-46-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,5,9 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 147591-46:
(8*1)+(7*4)+(6*7)+(5*5)+(4*9)+(3*1)+(2*4)+(1*6)=156
156 % 10 = 6
So 147591-46-6 is a valid CAS Registry Number.
147591-46-6Relevant articles and documents
LACTAM AND ACID AMIDE ACETALS. 71. NEW SYNTHESIS OF 3-NITRO-6-HYDROXYINDOLE DERIVATIVES
Lyubchanskaya, V. M.,Alekseeva, L. M.,Granik, V. G.
, p. 34 - 39 (2007/10/02)
Previously unknown 3-nitro-6-hydroxyindole derivatives were synthesized by condensation of p-benzoquinone with secondary β-nitro enamines.
