147596-36-9Relevant academic research and scientific papers
One-pot synthesis of spiro isochromane-3,3'-piperidines, -3,4'-piperidines and -3,3'-pyrrolidines
Butcher,Claremon
, p. 211 - 212 (1993)
Spiro isochromane-1-ones 1 were treated with lithium aluminum hydride or Grignard reagents to afford diol intermediates 2, which cyclize in 85% phosphoric acid at 100°C to spiro isochromanes 3 in 72-94% isolated yields.
