147597-18-0

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 88488-48-6 2-nitrooxyethyl 3-oxobutanoate 
• 88488-47-5 2-bromoethyl acetoacetate 

Downstream Products

• 103434-79-3 2,6-dimethyl-4-(3-nitrophenyl)-3-(2-nitrooxyethoxy)carbonyl-1,4-dihydropyridine-5-carboxylic acid 
• 103434-73-7 2-nitrooxyethyl 2-cyanoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 

Relevant academic research and scientific papers

Novel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxyalkoxycarbonyl groups at 3- and/or 5-position

Novel 2-amino-1,4-dihydropyridine derivatives, which contain nitroxy-alkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing a nitrooxy moiety at the 3-ester position

The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.