14760-44-2Relevant academic research and scientific papers
Artifacts formed in the metabolic study of pethidine
Stillwell,Lindberg,Hartvig
, p. 71 - 75,72, 74 (2007/10/08)
The condensation of primary and secondary amines with formaldehyde from various sources has caused much confusion in the areas of drug metabolism and biogenic amine metabolism. Nelson et al. identified condensation products of a metabolite of lidocaine and acetaldehyde or formaldehyde present in organic solvents. Biogenic amines have also been found to condense with formaldehyde, enzymatically formed in vivo from 5 methyltetrahydrofolic acid. The presence of N-formylnorpethidine must be due to a condensation between norpethidine and formaldehyde from the organic solvent and/or from biological sources.
