CDKN1B, also known as cyclin-dependent kinase inhibitor 1B or p27, is a regulatory protein that functions as a tumor suppressor. It plays a critical role in the control of cell proliferation by inhibiting the activity of cyclin-dependent kinase (CDK) enzymes, which are essential for cell cycle progression. CDKN1B is involved in regulating the G1 to S phase transition of the cell cycle and is often downregulated in various types of cancer, leading to uncontrolled cell growth and tumor formation. Consequently, CDKN1B is a potential target for cancer therapy, and its dysregulation has been implicated in the development and progression of multiple types of cancer. Moreover, mutations in the CDKN1B gene can lead to the development of certain hereditary cancer syndromes. Overall, CDKN1B is a crucial player in the regulation of cell cycle progression, and its dysregulation can have profound implications for cancer development and progression.
147604-94-2
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Basic information
- Product Name: CDKN1B
- Synonyms: CDKN1B;Anti-p27 KIP1, C-Terminal antibody produced in rabbit;CDN1B;ANTI-PHOSPHO-MOUSE P27KIP1(T197) antibody produced in rabbit;Anti-p27 KIP1, N-Terminal antibody produced in rabbit;ANTI-27KIP1(C-TERMINAL) antibody produced in rabbit;ANTI-PHOSPHO-P27KIP1(T187) antibody produced in rabbit;ANTI-MOUSE P27KIP1 (C-TERM T197) antibody produced in rabbit
- CAS NO:147604-94-2
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: N/A
- CAS DataBase Reference: CDKN1B(CAS DataBase Reference)
- NIST Chemistry Reference: CDKN1B(147604-94-2)
- EPA Substance Registry System: CDKN1B(147604-94-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 147604-94-2(Hazardous Substances Data)
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147604-94-2 Usage
Uses
Used in Cancer Therapy:CDKN1B is used as a therapeutic target for the treatment of various types of cancer. Its role in controlling cell proliferation makes it a promising candidate for developing targeted therapies that can restore normal cell cycle regulation and inhibit tumor growth.
Used in Cancer Research:
CDKN1B is used as a biomarker for cancer diagnosis and prognosis. Its downregulation in various cancers can provide valuable information about the aggressiveness and progression of the disease, helping in the development of personalized treatment strategies.
Used in Drug Development:
CDKN1B is used as a target for the development of small molecule inhibitors or activators that can modulate its activity and restore its tumor suppressor function. These drugs can potentially be used in combination with existing cancer therapies to enhance their efficacy and overcome drug resistance.
Used in Genetic Counseling and Screening:
Mutations in the CDKN1B gene can lead to the development of certain hereditary cancer syndromes. Therefore, CDKN1B is used as a genetic marker for screening and counseling individuals with a family history of cancer, allowing for early detection and intervention.
Used in Cancer Prevention:
Understanding the role of CDKN1B in cell cycle regulation and its involvement in cancer development can help in the identification of lifestyle and environmental factors that may influence its expression and function. This knowledge can be used to develop strategies for cancer prevention and risk reduction.
Check Digit Verification of cas no
The CAS Registry Mumber 147604-94-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,6,0 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.Calculate Digit Verification of CAS Registry Number 147604-94:
(8*1)+(7*4)+(6*7)+(5*6)+(4*0)+(3*4)+(2*9)+(1*4)=142
142 % 10 = 2
So 147604-94-2 is a valid CAS Registry Number.
147604-94-2Upstream product
147604-94-2Downstream Products
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CDKN1B
