147604-94-2

Basic information

• Product Name: CDKN1B
• Synonyms: CDKN1B;Anti-p27 KIP1, C-Terminal antibody produced in rabbit;CDN1B;ANTI-PHOSPHO-MOUSE P27KIP1(T197) antibody produced in rabbit;Anti-p27 KIP1, N-Terminal antibody produced in rabbit;ANTI-27KIP1(C-TERMINAL) antibody produced in rabbit;ANTI-PHOSPHO-P27KIP1(T187) antibody produced in rabbit;ANTI-MOUSE P27KIP1 (C-TERM T197) antibody produced in rabbit
• CAS NO: 147604-94-2
• Molecular Weight: 0
• Mol File: 147604-94-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: CDKN1B(CAS DataBase Reference)
• NIST Chemistry Reference: CDKN1B(147604-94-2)
• EPA Substance Registry System: CDKN1B(147604-94-2)

Safety Data

• Hazardous Substances Data: 147604-94-2(Hazardous Substances Data)

Usage

General Description

CDKN1B, also known as cyclin-dependent kinase inhibitor 1B or p27, is a regulatory protein that functions as a tumor suppressor. It plays a critical role in the control of cell proliferation by inhibiting the activity of cyclin-dependent kinase (CDK) enzymes, which are essential for cell cycle progression. CDKN1B is involved in regulating the G1 to S phase transition of the cell cycle and is often downregulated in various types of cancer, leading to uncontrolled cell growth and tumor formation. Consequently, CDKN1B is a potential target for cancer therapy, and its dysregulation has been implicated in the development and progression of multiple types of cancer. Moreover, mutations in the CDKN1B gene can lead to the development of certain hereditary cancer syndromes. Overall, CDKN1B is a crucial player in the regulation of cell cycle progression and its dysregulation can have profound implications for cancer development and progression.